ArticleArchives of disease in childhood. Fetal and neonatal edition2022
Reduced health-related quality of life in children born extremely preterm in 2006 compared with 1995: the EPICure Studies.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Socioeconomic outcomes in very preterm/very low birth weight adults: individual participant data meta-analysis.Pediatric research · 2025Pooled it
- Neurodevelopment and Growth 2 Years After Probiotic Supplementation in Extremely Preterm Infants: A Randomised Trial.Acta paediatrica (Oslo, Norway : 1992) · 2025Trial
- Parent-reported quality of life at school age among children born extremely preterm is associated with non-medical determinants of health and developmental outcomes.Early human development · 2026Article
- Severe neonatal complications and long-term health-related quality of life in very preterm and/or very low birth weight survivors: evidence from the Dutch Project on preterm and small for gestational age cohort.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Heterogeneous, temporally consistent, and plastic brain development after preterm birth.Nature communications · 2025Article
- Tracking visual outcomes - Follow-up on patients born preterm with childhood-onset visual impairment.Acta ophthalmologica · 2025Article
- Comparing the Prevalence of Psychiatric Disorders in Cohorts of Children Born Extremely Preterm in 1995 and 2006: The EPICure Studies.JAACAP open · 2024Article
- The Ethics and Practice of Periviability Care.Children (Basel, Switzerland) · 2024Article
- Health-Related Quality of Life for Parents of Infants with Bronchopulmonary Dysplasia.The Journal of pediatrics · 2024Article
- Psychometric Performance of Generic Childhood Multi-Attribute Utility Instruments in Preterm and Low Birthweight Populations: A Systematic Review.Children (Basel, Switzerland) · 2023Review
- Health-Related Qualities of Life in School-Aged Children with Bronchopulmonary Dysplasia.The Journal of pediatrics · 2023Observational
- Quality of Life at a 10-Year Follow-Up of Children Born Preterm with Post-Hemorrhagic Ventricular Dilatation: A Cohort Study.Neonatology · 2023Article
- Health-related quality of life of children born very preterm: a multinational European cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo compare health-related quality of life (HRQL) in childhood for extremely preterm (EP) births before 26 weeks of gestation in England in two eras: 1995 and 2006.
designProspective cohort studies.
settingSchool or home-based assessments at 11 years of age.
participantsAvailable data for 88 EP children born before 26 weeks of gestation in 2006 (EPICure2) were compared with those of 140 born in England during 1995 (EPICure). To account for social secular trends, the comparison between eras was also made for term-born controls as reference.
main outcome measuresHRQL was measured using the parent-completed Health Utilities Index (HUI) questionnaire with utility scores calculated using the HUI3 classification system. Eight attributes were assessed: vision, hearing, speech, ambulation, dexterity, emotion, cognition and pain.
resultsAt 11 years, mean utility scores were significantly lower in EPICure2 (2006) than in EPICure (1995; Δ -0.12, 95% CI -0.20 to -0.04). The difference increased (Δ -0.27, 95% CI -0.41 to -0.12) after adjusting for significant perinatal and demographic differences between cohorts. Rates of suboptimal function were increased in EPICure2 for all eight attributes, but statistically significant differences were only found in speech (p=0.004) and dexterity (p=0.020). After excluding children with severe neurodevelopmental impairment, the adjusted difference between cohorts remained significant but attenuated (-0.14 (-0.26 to -0.01)). Mean utility scores for controls were similar between cohorts (Δ -0.01 (-0.04 to 0.02)).
conclusionsUsing parent report, there was a clinically significant decline in HRQL ratings for EP children over time. Areas contributing the most to the decline were speech and dexterity. TRIAL REGISTRATION NUMBER: ISRCTN86323684.
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