ArticleBMC pediatrics2021
Factors associated with mortality of pediatric sepsis patients at the pediatric intensive care unit in a low-resource setting.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association between fluid overload and mortality in children with sepsis: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- The magnitude of pediatric mortality and determinant factors in intensive care units in a low-resource country, Ethiopia: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- Utilizing Machine Learning for Diagnostic Assistance of Pediatric Sepsis and Septic Shock in Resource-Limited Settings.Pediatric reports · 2026Article
- Pediatric Emergency Department Care for Septic Shock in Sub-Saharan Africa: Single-Center Outcomes Before-Vs.-After Implementation of a Telesimulation Program, 2023-2024.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Article
- Base deficit and alactic base excess are promising early biological markers in pediatric sepsis.BMC pediatrics · 2026Article
- On the usage of artificial intelligence for identifying main attributes and predicting neonatal sepsis.Scientific reports · 2026Article
- Clinical profile, intensive care needs, outcome, and predictors of mortality in children with severe sepsis: Secondary analysis of FerriPedS study.The Indian journal of medical research · 2026Article
- Hemodynamic monitoring in sepsis and septic shock in pediatric patients: a multicenter survey.Critical care science · 2026Article
- Utility of the Phoenix-8 and PELOD-2 scales in pediatric patients with sepsis and acute lymphoblastic leukemia admitted to a pediatric intensive care unit at a quaternary-level hospital in Bogotá, Colombia, 2022-2024.Frontiers in pediatrics · 2026Article
- Risk Factors for Bloodstream Infections in Critically Ill Children: Gram-Negative Predominance and Complex Chronic Conditions.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Factors and outcomes of pediatric sepsis under an antimicrobial stewardship program in a tertiary care teaching hospital in Thailand: a retrospective cohort study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Factors associated with mortality in pediatric septic shock in Thai children with long-term survival analysis post-hospital discharge: a nationwide study 2015-2022.Scientific reports · 2025Article
- Escherichia coli causing bloodstream infections in Mexican paediatric patients: molecular typing, antimicrobial resistance, virulence factors, and clinical features.BMC infectious diseases · 2025Article
- NEED FOR INTENSIVE CARE UNIT ADMISSION, MORTALITY RATE AND ASSOCIATED FACTORS USING PAEDIATRIC ADVANCED WARNING SCORE (PAWS) ON ARRIVAL AT HOSPITAL: HOSPITAL BASED PROSPECTIVE STUDY.International journal of science academic research · 2025Article
- Impact of an Antimicrobial Stewardship program on mortality and consumption of antibiotics in the intensive care units of a pediatric referral hospital in Peru.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Epidemiology and outcomes of septic shock in Thai children: a nationwide retrospective study from 2015 to 2022.Critical care (London, England) · 2024Article
- An update on the role of fluid overload in the prediction of outcome in acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Review
- Survey of Thai Physicians' Practice in Pediatric Septic Shock.Children (Basel, Switzerland) · 2024Article
- Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Hematological Indices for Identifying Adverse Outcomes in Children Admitted to Pediatric ICUs.Cureus · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is the leading cause of death worldwide in pediatric populations. Studies in low-resource settings showed that the majority of pediatric patients with sepsis still have a high mortality rate.
methodsWe retrospectively collected records from 2014 to 2019 of patients who had been diagnosed with sepsis and admitted to PICU in our tertiary hospital. Cox proportional hazard regression modeling was used to evaluate associations between patient characteristics and mortality.
resultsOverall, 665 patients were enrolled in this study, with 364 (54.7%) boys and 301 (46.3%) girls. As many as 385 patients (57.9%) died during the study period. The median age of patients admitted to PICU were 1.8 years old with interquartile range (IQR) ±8.36 years and the median length of stay was 144 h (1-1896 h). More than half 391 patients (58.8%) had a good nutritional status. Higher risk of mortality in PICU was associated fluid overload percentage of > 10% (HR 9.6, 95% CI: 7.4-12.6), the need of mechanical ventilation support (HR 2.7, 95% CI: 1.6-4.6), vasoactive drugs (HR 1.5, 95% CI: 1.2-2.0) and the presence of congenital anomaly (HR 1.4, 95% CI: 1.0-1.9). On the contrary, cerebral palsy (HR 0.3, 95% CI: 0.1-0.5) and post-operative patients (HR 0.4, 95% CI: 0.3-0.6) had lower mortality.
conclusionPICU mortality in pediatric patients with sepsis is associated with fluid overload percentage of > 10%, the need for mechanical ventilation support, the need of vasoactive drugs, and the presence of congenital anomaly. In septic patients in PICU, those with cerebral palsy and admitted for post-operative care had better survival.
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