ArticleBMC geriatrics2021
Prevalence of cognitive impairment in Chinese older inpatients and its relationship with 1-year adverse health outcomes: a multi-center cohort study.
Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 29 citations in OpenAlex.
- How health literacy and eHealth literacy influence quality of life in older adults with chronic diseases: a network and path analysis.Health and quality of life outcomes · 2026Article
- Cross-cultural adaptation and psychometric evaluation of the Chinese version of the short version of the Cognitive Reserve Index Questionnaire (s-CRIq): a cross-sectional study.BMC psychiatry · 2026Article
- Chinese-specific dietary patterns and cognitive function in Chinese older adults: a cross-lagged panel network analysis.European journal of nutrition · 2026Article
- The mediating effect of arteriosclerosis on the relationship between sarcopenia and cognitive impairment: a retrospective analysis.Frontiers in medicine · 2026Article
- The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty.Frontiers in cellular and infection microbiology · 2026Review
- Atherogenic index of plasma and cognitive impairment risk among hypertensive adults: evidence from a nationwide cohort study.Aging clinical and experimental research · 2025Article
- Association between basal metabolic rate and cognitive function in Chinese older adults: the mediating effect of sarcopenia.BMC geriatrics · 2025Article
- The Impact of Socioeconomic Factors on Cognitive Ability in Community-Dwelling Older Adults: Mediating Effect of Social Participation and Social Support.Healthcare (Basel, Switzerland) · 2025Article
- The relationship between sarcopenia and mental health status in Chinese older adults: the mediating role of activities of daily living.BMC geriatrics · 2025Article
- A trajectory study of postoperative frailty and cognitive function in elderly spinal surgery patients: a cohort study in China.Frontiers in aging neuroscience · 2025Article
- Influencing factors of health utility values in older adult people with normal cognition or mild cognitive impairment: a cross-sectional survey.Frontiers in public health · 2025Article
- Exploring the impact of internet use on cognitive abilities in the older adults: evidence from the CHARLS 2020 database.Frontiers in public health · 2025Article
- Association of cognitive performance with overall, dosage, intensity, and domain physical activity in aging: NHANES 2011-2014.BMC geriatrics · 2024Article
- Cognitive impairment in young and middle-aged patients with acute heart failure.ESC heart failure · 2024Article
- Independent and combined associations of depression and cognitive impairment with frailty in oldest-old adults.BMC psychology · 2024Article
- The Longitudinal Dyadic Associations Between Social Participation and Cognitive Function in Older Chinese Couples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Article
- Joint association of serum sodium and frailty with mild cognitive impairment among hospitalized older adults with chronic diseases: a cross-sectional study.Frontiers in nutrition · 2024Article
- Trajectories of cognitive function and frailty in older adults in China: a longitudinal study.Frontiers in aging neuroscience · 2024Article
- Relationship between triglyceride-glucose index and cognitive function among community-dwelling older adults: a population-based cohort study.Frontiers in endocrinology · 2024Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies on the relationship between cognitive impairment and adverse outcomes among geriatric inpatients are not representative of older inpatients in China because of insufficient sample sizes or single-center study designs. The purpose of our study was to examine the prevalence of cognitive impairment and the relationship between cognitive impairment and 1-year adverse health outcomes in older inpatients.
methodsThis study was a large-scale multi-center cohort study conducted from October 2018 to February 2020. Six tertiary hospitals across China were selected using a two-stage cluster sampling method, and eligible older inpatients were selected for the baseline survey and follow-up. The Mini Cognitive Scale and the FRAIL scale were used to screen for cognitive impairment and frailty, respectively. The EuroQol-5 Dimension-5 Level questionnaire was used to assess health-related quality of life (HRQoL). We used a generalized estimating model to evaluate the relationship between cognitive impairment and adverse outcomes.
resultsThe study included 5008 men (58.02%) and 3623 women (41.98%), and 70.64% were aged 65-75 years, and 26.27% were aged 75-85 years. Cognitive impairment was observed in 1756 patients (20.35%). There were significant differences between participants with cognitive impairment and those with normal cognitive function for age, gender, surgery status, frailty, depression, handgrip strength and so on. After adjusting for multiple covariates, compared with patients with normal cognitive function, the odds ratio for 1-year mortality was 1.216 (95% confidence interval [CI]: 1.076-1.375) and for 1-year incidence of frailty was 1.195 (95% CI: 1.037-1.376) in patients with cognitive impairment. Similarly, the regression coefficient of 1-year HRQoL was - 0.013 (95% CI: - 0.024-- 0.002). In the stratified analysis, risk of adverse outcome within 1 year was higher in older patients with cognitive impairment aged over 75 years than those aged 65-74 years.
conclusionsWe revealed that cognitive impairment was highly correlated with occurrence of 1-year adverse health outcomes (death, frailty, and decreased HRQoL) in older inpatients, which provides a basis for formulating effective intervention measures.
trial registrationChinese Clinical Trial Registry, ChiCTR1800017682 , registered 09 August 2018.
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