Evidence map›Paper›PMID 34696668›Full record

ArticleBioengineered2021

MicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1).

Zhiqun Li, Xiaoliu Zhou, Jiajun Huang, Zhencai Xu, Chengliang Xing, Junwei Yang, Xuejun Zhou

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. [Research Progress on the Role and Mechanisms of PYCR1 
in Tumorigenesis and Progression].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhiqun LiDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Xiaoliu ZhouDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Jiajun HuangDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Zhencai XuDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Chengliang XingDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Junwei YangDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Xuejun ZhouDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Hainan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal cancer is a rare cancer type, but with a low five-year survival rate. Dysregulation of pyrroline-5-carboxylate reductase 1 (PYCR1) and microRNA hsa-miR-150-5p is involved in the development of various cancers. However, the molecular mechanism of the hsa-miR-150-5p-PYCR1 axis in nasopharyngeal cancer remains unclear. To identify the mechanism of the hsa-miR-150-5p-PYCR1 axis, the expression of hsa-miR-150-5p and PYCR1 in nasopharyngeal cancer tissues and cells was first measured by reverse transcription quantitative polymerase chain reaction. The luciferase and RNA pull-down assays were used to confirm the interaction between hsa-miR-150-5p and PYCR1. The overexpression of hsa-miR-150-5p and PYCR1 was detected by cell viability, proliferation, western blotting, migration, and invasion in nasopharyngeal cancer cells. The expression levels of hsa-miR-150-5p was reduced in the nasopharyngeal cancer tissues and cells and were negatively correlated with the PYCR1 levels. The upregulation of hsa-miR-150-5p significantly repressed cell growth and promoted apoptosis. However, the upregulation of

Indexed as

CarcinogenesisCell Line, Tumordelta-1-Pyrroline-5-Carboxylate ReductaseHumansMicroRNAsNasopharyngeal NeoplasmsNeoplasm ProteinsPyrroline Carboxylate ReductasesRNA, Neoplasmdelta-1-Pyrroline-5-Carboxylate ReductaseMicroRNAsMIR150, humanNeoplasm ProteinsPyrroline Carboxylate ReductasesRNA, NeoplasmHsa-miR-150-5pnasopharyngeal cancerPYCR1

Identifiers

PMID34696668
PMCPMC8810012
OpenAlexW3209088551

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.