Evidence map›Paper›PMID 34696534›Full record

ArticleViruses2021

Near-Complete Genome of SARS-CoV-2 Delta (AY.3) Variant Identified in a Dog in Kansas, USA.

Tyler Doerksen, Andrea Lu, Lance Noll, Kelli Almes, Jianfa Bai, David Upchurch, Rachel Palinski

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. SARS-CoV-2 and natural infection in animals.Journal of medical virology · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tyler DoerksenVeterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, 2005 Research Park, Manhattan, KS 66502, USA.
Andrea LuVeterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, 2005 Research Park, Manhattan, KS 66502, USA.
Lance NollVeterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, 2005 Research Park, Manhattan, KS 66502, USA.
Kelli AlmesVeterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, 2005 Research Park, Manhattan, KS 66502, USA.
Jianfa BaiVeterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, 2005 Research Park, Manhattan, KS 66502, USA.ORCID 0000-0002-0021-3036
David UpchurchVeterinary Health Center, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66502, USA.ORCID 0000-0001-7409-3957
Rachel PalinskiVeterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, 2005 Research Park, Manhattan, KS 66502, USA.ORCID 0000-0003-4120-8951

Funding

Sex-specific effects of obestity on Influenza A virus infection and immunityP20GM130448 · NIGMS · KANSAS STATE UNIVERSITY · PI WAITHAKA MWANGI · 2020 to 2026
$15.8M
NIGMS NIH HHS P20 GM130448NIH HHS P20GM130448United States Department of Agriculture 1026878
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) descriptions of infection and transmission have been increasing in companion animals in the past year. Although canine susceptibility is generally considered low, their role in the COVID-19 disease cycle remains unknown. In this study, we detected and sequenced a delta variant (AY.3) from a 12-year-old Collie living with owners that previously tested positive for SARS-CoV-2. It is unclear if the dogs' symptoms were related to SARS-CoV-2 infection or underlying conditions. The whole genome sequence obtained from the dog sample had several unique consensus level changes not previously identified in a SARS-CoV-2 genome that may play a role in the rapid adaptation from humans to dogs. Within the spike coding region, 5/7 of the subconsensus variants identified in the dog sequence were also identified in the closest in-house human reference case. Taken together, the whole genome sequence, and phylogenetic and subconsensus variant analyses indicate the virus infecting the animal originated from a local outbreak cluster. The results of these analyses emphasize the importance of rapid detection and characterization of SARS-CoV-2 variants of concern in companion animals.

Indexed as

AnimalsCOVID-19Disease ReservoirsDog DiseasesDogsGenome, ViralKansasMaleSARS-CoV-2Whole Genome SequencingAY.3canineCOVID-19delta variantdogSARS-CoV-2

Identifiers

PMID34696534
PMCPMC8541569

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.