Evidence map›Paper›PMID 34696480›Full record

ArticleViruses2021

Rapid and Successful Implementation of a COVID-19 Convalescent Plasma Programme-The South African Experience.

Tanya Nadia Glatt, Caroline Hilton, Cynthia Nyoni, Avril Swarts, Ronel Swanevelder, James Cowley, Cordelia Mmenu, Thandeka Moyo-Gwete, Penny L Moore, Munzhedzi Kutama and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Tanya Nadia GlattMedical Division, South African National Blood Service, Roodepoort 1709, South Africa.ORCID 0000-0002-5458-5791
Caroline HiltonMedical Division, Western Cape Blood Service, Cape Town 7405, South Africa.
Cynthia NyoniMedical Division, South African National Blood Service, Roodepoort 1709, South Africa.ORCID 0000-0003-3547-9413
Avril SwartsMedical Division, South African National Blood Service, Roodepoort 1709, South Africa.
Ronel SwanevelderMedical Division, South African National Blood Service, Roodepoort 1709, South Africa.
James CowleyOperations Division, South African National Blood Service, Roodepoort 1709, South Africa.
Cordelia MmenuOperations Division, South African National Blood Service, Roodepoort 1709, South Africa.
Thandeka Moyo-GweteNational Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg 2192, South Africa.ORCID 0000-0002-4269-9281
Penny L MooreNational Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg 2192, South Africa.
Munzhedzi KutamaOperations Division, South African National Blood Service, Roodepoort 1709, South Africa.
Jabulisile JazaOperations Division, South African National Blood Service, Roodepoort 1709, South Africa.
Itumeleng PhayaneOperations Division, South African National Blood Service, Roodepoort 1709, South Africa.ORCID 0000-0001-8059-8062
Tinus BritsInformation Technology Division, South African National Blood Service, Roodepoort 1709, South Africa.
Johan KoekemoerInformation Technology Division, South African National Blood Service, Roodepoort 1709, South Africa.
Ute JentschMedical Division, South African National Blood Service, Roodepoort 1709, South Africa.
Derrick NelsonMedical Division, South African National Blood Service, Roodepoort 1709, South Africa.
Karin van den BergMedical Division, South African National Blood Service, Roodepoort 1709, South Africa.ORCID 0000-0001-9805-8013
Marion VermeulenOperations Division, South African National Blood Service, Roodepoort 1709, South Africa.ORCID 0000-0003-4383-4526
South African National Blood Service · ZANational Health Laboratory Service · ZAUniversity of Cape Town · ZAUniversity of the Free State · ZA

Funding

Research training in HIV-related transfusion medicine and hematology in South AfricaD43TW010345 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI UTE JENTSCH, EDWARD L MURPHY · 2017 to 2026
$3.0M
Allan & Gill Gray Philanthropy LIMITED 20-FIC NIH HHS D43 TW010345National Research Foundation of South Africa 98341NIH Fogarty International Center training grant 1D43-TW010345South African Medical Research Council (Department of Science and Innovation) 20-South African Medical Research Council (SHIP program) 20-The ELMA South Africa Foundation 20-ESA011
6 · The paper itself

Abstract

backgroundCOVID-19 convalescent plasma (CCP) has been considered internationally as a treatment option for COVID-19. CCP refers to plasma collected from donors who have recovered from and made antibodies to SARS-CoV-2. To date, convalescent plasma has not been collected in South Africa. As other investigational therapies and vaccination were not widely accessible, there was an urgent need to implement a CCP manufacture programme to service South Africans.

methodsThe South African National Blood Service and the Western Cape Blood Service implemented a CCP programme that included CCP collection, processing, testing and storage. CCP units were tested for SARS-CoV-2 Spike ELISA and neutralising antibodies and routine blood transfusion parameters. CCP units from previously pregnant females were tested for anti-HLA and anti-HNA antibodies.

resultsA total of 987 CCP units were collected from 243 donors, with a median of three donations per donor. Half of the CCP units had neutralising antibody titres of >1:160. One CCP unit was positive on the TPHA serology. All CCP units tested for anti-HLA antibodies were positive.

conclusionWithin three months of the first COVID-19 diagnosis in South Africa, a fully operational CCP programme was set up across South Africa. The infrastructure and skills implemented will likely benefit South Africans in this and future pandemics.

Indexed as

AdultAgedAntibodies, NeutralizingAntibodies, ViralBlood Component RemovalBlood DonorsCOVID-19COVID-19 SerotherapyFemaleHumansImmunization, PassiveMaleMiddle AgedSARS-CoV-2South AfricaSpike Glycoprotein, CoronavirusAntibodies, NeutralizingAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2convalescent plasmaCOVID-19SARS-CoV-2

Identifiers

PMID34696480
PMCPMC8539971
OpenAlexW3207667556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.