Evidence map›Paper›PMID 34696479›Full record

ArticleViruses2021

Phage Therapy Related Microbial Succession Associated with Successful Clinical Outcome for a Recurrent Urinary Tract Infection.

Austen Terwilliger, Justin Clark, Maile Karris, Haroldo Hernandez-Santos, Sabrina Green, Saima Aslam, Anthony Maresso

Registry-linked trialOpen access · goldAbstract readCase Reports
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06559618 (A Phase 1B Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria), which is not on this map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06559618 phase1recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase 1B Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria

TypeinterventionalSponsorBarbara TrautnerRan2025 to 2028Enrolled30ConditionsBacteriuria, Spinal Cord Injuries, Asymptomatic Bacteriuria, Escherichia ColiArmsPhage Therapy, Placebo
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 76 citations in OpenAlex.

  1. UropathogenicAntibiotics (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Discovery and characterization of a novelPHAGE (New Rochelle, N.Y.) · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Bacteriophage-mediated reduction of uropathogenicbioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Phage-induced protection against lethal bacterial reinfection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Present and future of microbiome-targeting therapeutics.The Journal of clinical investigation · 2025
    Review
  17. [Potential of bacteriophage therapy in Germany: evidence and clinical relevance].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025
    Review
  18. Treatment ofViruses · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Austen TerwilligerTAILΦR Labs, Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, TX 77030, USA.
Justin ClarkTAILΦR Labs, Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-1590-6828
Maile KarrisCenter for Innovative Phage Applications and Therapeutics, Division of Infectious Diseases and Global Public Health, University of California, San Diego, CA 92093, USA.
Haroldo Hernandez-SantosTAILΦR Labs, Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, TX 77030, USA.
Sabrina GreenTAILΦR Labs, Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, TX 77030, USA.
Saima AslamCenter for Innovative Phage Applications and Therapeutics, Division of Infectious Diseases and Global Public Health, University of California, San Diego, CA 92093, USA.
Anthony MaressoTAILΦR Labs, Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, TX 77030, USA.
Baylor College of Medicine · USUniversity of California San Diego · US

Funding

NIH HHS AI15798
6 · The paper itself

Abstract

We rationally designed a bacteriophage cocktail to treat a 56-year-old male liver transplant patient with complex, recurrent prostate and urinary tract infections caused by an extended-spectrum beta-lactamase (ESBL)-producing

Indexed as

Anti-Bacterial AgentsBacteriophagesEscherichia coliEscherichia coli InfectionsHumansLiver TransplantationMaleMicrobial Sensitivity TestsMiddle AgedPhage TherapyPrecision MedicineTransplant RecipientsUrinary Tract InfectionsVirulenceAnti-Bacterial Agentscomparative genomicshumoral responsemicrobial pathogenesisphage therapyUTI

Identifiers

PMID34696479
PMCPMC8541385
OpenAlexW3205963203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.