Evidence map›Paper›PMID 34696441›Full record

ArticleViruses2021

Neutralization of SARS-CoV-2 Variants by Serum from BNT162b2 Vaccine Recipients.

Fabrizia Valleriani, Elisa Mancuso, Giacomo Vincifori, Liana Teodori, Lisa Di Marcantonio, Massimo Spedicato, Alessandra Leone, Giovanni Savini, Daniela Morelli, Barbara Bonfini and 1 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Fabrizia VallerianiIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.ORCID 0000-0002-8049-6282
Elisa MancusoIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.
Giacomo VinciforiIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.
Liana TeodoriIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.
Lisa Di MarcantonioIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.ORCID 0000-0002-2369-2017
Massimo SpedicatoIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.
Alessandra LeoneIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.
Giovanni SaviniIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.
Daniela MorelliIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.
Barbara BonfiniIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.ORCID 0000-0002-6001-9833
Alessio LorussoIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, 641000 Teramo, Italy.ORCID 0000-0001-6156-8212
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale · IT

Funding

European Union's Horizon 2020 Research and Innovation program under grant agreement No 773830Italian Ministry of Health IZSAM 05/20 Ricerca Corrente 2020 "PanCO: epidemiologia e patogenesi dei coronavirus umani ed animaliItalian Ministry of Health Ricerca Strategica 2020, "Suscettibilità dei mammiferi a SARS-COV-2: rischi di zoonosi inversa e possibilità in medicina traslazionale
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly, leading to viral lineages characterized by multiple mutations in the spike protein, which could potentially confer to the virus the ability to avoid the vaccine-induced immune response, making the vaccines less effective or ineffective. Here, we initially evaluated the neutralization capabilities in vitro by serum neutralization (SN) of six serum samples collected from recipients of the BNT162b2 vaccine against 11 SARS-CoV-2 isolates belonging to the major SARS-CoV-2 lineages that had been circulating in Italy. Then, we considered 30 additional serum samples by SN assay against the dominant B.1.617.2 (Delta) variant. A B.1 lineage isolate was used as a reference. In the first analysis, significant differences when compared with the reference strain (

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCell LineChlorocebus aethiopsCOVID-19COVID-19 SerotherapyCOVID-19 VaccinesHumansImmunization, PassiveItalyNeutralization TestsSARS-CoV-2Vero CellsAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesB.1.617.2 (Delta) variantcellsneutralizationSARS-CoV-2variantsviruses

Identifiers

PMID34696441
PMCPMC8540752
OpenAlexW3204726765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.