Evidence map›Paper›PMID 34696386›Full record

ArticleViruses2021

Characterizing the Countrywide Epidemic Spread of Influenza A(H1N1)pdm09 Virus in Kenya between 2009 and 2018.

D Collins Owuor, Zaydah R de Laurent, Gilbert K Kikwai, Lillian M Mayieka, Melvin Ochieng, Nicola F Müller, Nancy A Otieno, Gideon O Emukule, Elizabeth A Hunsperger, Rebecca Garten and 4 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

D Collins OwuorWellcome Trust Research Programme, Epidemiology and Demography Department, Kenya Medical Research Institute (KEMRI), Kilifi 230-80108, Kenya.
Zaydah R de LaurentWellcome Trust Research Programme, Epidemiology and Demography Department, Kenya Medical Research Institute (KEMRI), Kilifi 230-80108, Kenya.
Gilbert K KikwaiKenya Medical Research Institute (KEMRI), Nairobi 54840-00200, Kenya.
Lillian M MayiekaKenya Medical Research Institute (KEMRI), Nairobi 54840-00200, Kenya.
Melvin OchiengKenya Medical Research Institute (KEMRI), Nairobi 54840-00200, Kenya.
Nicola F MüllerFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA 98109, USA.
Nancy A OtienoKenya Medical Research Institute (KEMRI), Nairobi 54840-00200, Kenya.
Gideon O EmukuleCenters for Disease Control and Prevention (CDC), Influenza Division, Nairobi 606-00621, Kenya.
Elizabeth A HunspergerCenters for Disease Control and Prevention, Division of Global Health Protection, Nairobi 606-00621, Kenya.
Rebecca GartenInfluenza Division, National Center for Immunization and Respiratory Diseases (NCIRD), Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
John R BarnesInfluenza Division, National Center for Immunization and Respiratory Diseases (NCIRD), Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Sandra S ChavesCenters for Disease Control and Prevention (CDC), Influenza Division, Nairobi 606-00621, Kenya.ORCID 0000-0002-9453-7057
D James NokesWellcome Trust Research Programme, Epidemiology and Demography Department, Kenya Medical Research Institute (KEMRI), Kilifi 230-80108, Kenya.
Charles N AgotiWellcome Trust Research Programme, Epidemiology and Demography Department, Kenya Medical Research Institute (KEMRI), Kilifi 230-80108, Kenya.
Kenya Medical Research Institute · KECenters for Disease Control and Prevention · USCenters for Disease Control and Prevention · KEFred Hutch Cancer Center · USPwani University · KE

Funding

CDC HHS GH002133Wellcome Trust 1029745Wellcome Trust 107769/Z/10/Z
6 · The paper itself

Abstract

The spatiotemporal patterns of spread of influenza A(H1N1)pdm09 viruses on a countrywide scale are unclear in many tropical/subtropical regions mainly because spatiotemporally representative sequence data are lacking. We isolated, sequenced, and analyzed 383 A(H1N1)pdm09 viral genomes from hospitalized patients between 2009 and 2018 from seven locations across Kenya. Using these genomes and contemporaneously sampled global sequences, we characterized the spread of the virus in Kenya over several seasons using phylodynamic methods. The transmission dynamics of A(H1N1)pdm09 virus in Kenya were characterized by (i) multiple virus introductions into Kenya over the study period, although only a few of those introductions instigated local seasonal epidemics that then established local transmission clusters, (ii) persistence of transmission clusters over several epidemic seasons across the country, (iii) seasonal fluctuations in effective reproduction number (

Indexed as

EpidemicsGenome, ViralGenetic VariationHemagglutinin Glycoproteins, Influenza VirusHigh-Throughput Nucleotide SequencingHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanKenyaPhylogenyRNA, ViralSeasonsHemagglutinin Glycoproteins, Influenza VirusRNA, Viralhemagglutininnext-generation sequencingphylodynamicstransmission

Identifiers

PMID34696386
PMCPMC8539974
OpenAlexW3144104437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.