Evidence map›Paper›PMID 34696339›Full record

ArticleViruses2021

Interaction between NS1 and Cellular MAVS Contributes to NS1 Mitochondria Targeting.

Yeu-Yang Tseng, Chih-Ying Kuan, Masaki Mibayashi, Chi-Jene Chen, Peter Palese, Randy A Albrecht, Wei-Li Hsu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Yeu-Yang TsengGraduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan.
Chih-Ying KuanGraduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan.
Masaki MibayashiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Chi-Jene ChenDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Peter PaleseDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-0337-5823
Randy A AlbrechtDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4008-503X
Wei-Li HsuGraduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 402, Taiwan.ORCID 0000-0002-1392-163X
Icahn School of Medicine at Mount Sinai · USNational Chung Hsing University · TWThe Royal Melbourne Hospital · AU

Funding

NIH HHS NIH HHSN272201400008C
6 · The paper itself

Abstract

Influenza A virus nonstructural protein 1 (NS1) plays an important role in evading host innate immunity. NS1 inhibits interferon (IFN) responses via multiple mechanisms, including sequestering dsRNA and suppressing retinoic acid-inducible gene I (RIG-I) signaling by interacting with RIG-I and tripartite motif-containing protein 25 (TRIM25). In the current study, we demonstrated the mitochondrial localization of NS1 at the early stage of influenza virus infection. Since NS1 does not contain mitochondria-targeting signals, we suspected that there is an association between the NS1 and mitochondrial proteins. This hypothesis was tested by demonstrating the interaction of NS1 with mitochondrial antiviral-signaling protein (MAVS) in a RIG-I-independent manner. Importantly, the association with MAVS facilitated the mitochondrial localization of NS1 and thereby significantly impeded MAVS-mediated Type I IFN production.

Indexed as

A549 CellsDEAD Box Protein 58HEK293 CellsHumansImmunity, InnateInfluenza A virusInfluenza, HumanInterferonsMitochondriaProtein DomainsReceptors, ImmunologicSignal TransductionTranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesViral Nonstructural ProteinsDEAD Box Protein 58INS1 protein, influenza virusInterferonsReceptors, ImmunologicRIGI protein, humanTranscription FactorsTRIM25 protein, humanTripartite Motif ProteinsUbiquitin-Protein LigasesViral Nonstructural Proteinsinfluenza A virusMAVSmitochondriaNS1

Identifiers

PMID34696339
PMCPMC8537625
OpenAlexW3201237294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.