Evidence map›Paper›PMID 34696238›Full record

ArticleVaccines2021

Longitudinal Humoral Responses after COVID-19 Vaccination in Peritoneal and Hemodialysis Patients over Twelve Weeks.

Claudius Speer, Matthias Schaier, Christian Nusshag, Maximilian Töllner, Mirabel Buylaert, Florian Kälble, Paula Reichel, Julia Grenz, Caner Süsal, Martin Zeier and 4 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Neutralizing antibody response against the B.1.617.2 (delta) and the B.1.1.529 (omicron) variants after a third mRNA SARS-CoV-2 vaccine dose in kidney transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Observational
  15. Article
  16. Decreased response to the mRNA anti-SARS-CoV-2 vaccine in hepatitis B vaccine non-responders and frail patients treated with peritoneal dialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Claudius SpeerDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Matthias SchaierDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-1040-1150
Christian NusshagDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Maximilian TöllnerDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Mirabel BuylaertDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Florian KälbleDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Paula ReichelDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Julia GrenzDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Caner SüsalInstitute of Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Martin ZeierDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Paul SchnitzlerDepartment of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Christian MorathDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Katrin KleinDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Louise BenningDepartment of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-8366-2100
Heidelberg University · DEEuropean Molecular Biology Organization · DE

Funding

Dietmar Hopp Stiftung pending
6 · The paper itself

Abstract

It has been demonstrated that patients on hemo- or peritoneal dialysis are particularly susceptible to SARS-CoV-2 infection and impaired seroconversion compared to healthy controls. Follow-up data on vaccination response in dialysis patients is limited but is greatly needed to individualize and guide (booster) vaccination strategies. In this prospective, multicenter study we measured anti-spike S1 and neutralizing antibodies in 124 hemodialysis patients, 41 peritoneal dialysis patients, and 20 age- and sex-matched healthy controls over 12 weeks after homologous BNT162b2 vaccination. Compared to healthy controls, both hemodialysis and peritoneal dialysis patients had lower anti-S1 IgG antibodies (median (IQR) 7.0 (2.8-24.3) and 21.8 (5.8-103.9) versus 134.9 (23.8-283.6), respectively;

Indexed as

BNT162b2COVID-19COVID-19 vaccinationhemodialysishumoral responseperitoneal dialysisSARS-CoV-2vaccination strategy

Identifiers

PMID34696238
PMCPMC8539130
OpenAlexW3202792757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.