Evidence map›Paper›PMID 34696212›Full record

ReviewVaccines2021

A Systematic Review and Meta-Analysis of Seasonal Influenza Vaccination of Health Workers.

Tingting Li, Xiaoling Qi, Qin Li, Wenge Tang, Kun Su, Mengmeng Jia, Weizhong Yang, Yu Xia, Yu Xiong, Li Qi and 1 more

Abstract readReview
In one paragraph

Review in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Influenza Vaccine Effectiveness Against Illness and Asymptomatic Infection in 2022-2023: A Prospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Incidence of laboratory-confirmed influenza and RSV and associated presenteeism and absenteeism among healthcare personnel, Israel, influenza seasons 2016 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tingting LiChongqing Municipal Center for Disease Control and Prevention, Chongqing 400016, China.ORCID 0000-0002-8268-5132
Xiaoling QiAffiliated Stomatological Hospital of Chongqing Medical University, Chongqing 400016, China.
Qin LiChongqing Municipal Center for Disease Control and Prevention, Chongqing 400016, China.
Wenge TangChongqing Municipal Center for Disease Control and Prevention, Chongqing 400016, China.
Kun SuChongqing Municipal Center for Disease Control and Prevention, Chongqing 400016, China.
Mengmeng JiaSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Weizhong YangSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Yu XiaChongqing Municipal Center for Disease Control and Prevention, Chongqing 400016, China.
Yu XiongChongqing Municipal Center for Disease Control and Prevention, Chongqing 400016, China.
Li QiChongqing Municipal Center for Disease Control and Prevention, Chongqing 400016, China.
Luzhao FengSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.

Funding

Chongqing Health Commission Program 2019GDRC014
6 · The paper itself

Abstract

A systematic review and meta-analysis was conducted to estimate the pooled effect of influenza vaccinations for health workers (HWs). Nine databases were screened to identify randomized clinical trials and comparative observational studies that reported the effect of influenza vaccination among HWs. The risk ratio (RR), standardized mean difference, and 95% confidence interval (CI) were employed to study the effect size using fixed/random-effect models. Subgroup analyses and sensitivity analyses were conducted accordingly. Publication bias was examined. Sixteen studies (involving 7971 HWs from nine countries) were included after a comprehensive literature search. The combined RR regarding the incidence of laboratory-confirmed influenza was 0.36 (95% CI: 0.25 to 0.54), the incidence of influenza-like illness (ILI) was 0.69 (95% CI: 0.45 to 1.06), the absenteeism rate was 0.63 (95% CI: 0.46 to 0.86), and the integrated standardized mean difference of workdays lost was -0.18 (95% CI: -0.28 to -0.07) days/person. The subgroup analysis indicated that vaccination significantly decreases the incidence of laboratory-confirmed influenza in different countries, study populations, and average-age vaccinated groups. Influenza vaccinations could effectively reduce the incidence of laboratory-confirmed influenza, absenteeism rates, and workdays lost among HWs. It is advisable, therefore, to improve the coverage and increase the influenza vaccination count among HWs, which may benefit both workers and medical institutions.

Indexed as

absenteeism ratehealth workersincidence of laboratory-confirmed influenzainfluenza vaccinationmeta-analysis

Identifiers

PMID34696212
PMCPMC8537688

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.