Evidence map›Paper›PMID 34695838›Full record

ArticleNature2021

The conformational cycle of prestin underlies outer-hair cell electromotility.

Navid Bavi, Michael David Clark, Gustavo F Contreras, Rong Shen, Bharat G Reddy, Wieslawa Milewski, Eduardo Perozo

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The BK channel-NS1619 agonist complex reveals molecular insights into allosteric activation gating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
  8. Structural Mechanism of Prestin-Membrane Mechanotransduction.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  16. Hearing Loss and Audiogenic Seizures Induced by Hypofunctional Prestin Variants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Navid BaviDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Michael David ClarkDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Gustavo F ContrerasDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Rong ShenDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Bharat G ReddyDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Wieslawa MilewskiDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Eduardo PerozoDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA. eperozo@uchicago.edu.ORCID http://orcid.org/0000-0001-7132-2793
University of Chicago · US

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
Structural basis of Outer Hair Cell Electromotility at High ResolutionR01DC019833 · NIDCD · UNIVERSITY OF CHICAGO · PI PEROZO, EDUARDO A · 2021 to 2025
$2.4M
Structural and pharmacological dynamics of KCNQ2: A cryoEM and biophysics studyF30MH116647 · NIMH · UNIVERSITY OF CHICAGO · PI CLARK, MICHAEL DAVID · 2018 to 2020
$150k
NIDCD NIH HHS R01 DC019833NIGMS NIH HHS R01 GM116961NIGMS NIH HHS T32 GM007281NIMH NIH HHS F30 MH116647
6 · The paper itself

Abstract

The voltage-dependent motor protein prestin (also known as SLC26A5) is responsible for the electromotive behaviour of outer-hair cells and underlies the cochlear amplifier

Indexed as

Anion Transport ProteinsHair Cells, Auditory, OuterAnimalsAnionsCryoelectron MicroscopyMammalsProteinsSulfate TransportersAnionsAnion Transport ProteinsProteinsSulfate Transporters

Identifiers

PMID34695838
OpenAlexW3208756624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.