Evidence map›Paper›PMID 34695654›Full record

ArticleParkinsonism & related disorders2021

Executive function and dopamine response in Parkinson's disease freezing of gait.

Travis H Turner, Federico Rodriguez-Porcel, Philip Lee, Katherine Teague, Lisa Heidelberg, Shonna Jenkins, Gonzalo J Revuelta

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
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  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Travis H TurnerDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA. Electronic address: turnertr@musc.edu.
Federico Rodriguez-PorcelDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Philip LeeDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Katherine TeagueDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Lisa HeidelbergDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Shonna JenkinsDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Gonzalo J RevueltaDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Medical University of South Carolina · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
Identification of Gait and Imaging Markers for Freezing of Gait in Parkinson's DiseaseK23NS091391 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI REVUELTA, GONZALO JAVIER · 2015 to 2019
$982k
NCATS NIH HHS UL1 TR000062NINDS NIH HHS K23 NS091391
6 · The paper itself

Abstract

backgroundThis investigation examined whether aspects of attention and executive functioning differed between Parkinson's Disease (PD) patients with freezing of gait (FOG) based on responsiveness to dopamine. We also explored association of cognition with FOG severity and gait metrics.

methodsFifty-four individuals with PD completed the study protocol: 17 without freezing (PDC), 23 with dopa-responsive FOG (RFOG), and 14 with dopa-unresponsive (URFOG). Standardized neuropsychological tests assessed attention (focused and sustained), psychomotor speed, and set-switching (time and errors). FOG severity was measured using the new FOG Questionnaire (nFOG-Q). Metrics from timed up and go (TUG) tasks were obtained while "on" and "off" dopamine, with and without dual cognitive tasks.

resultsAfter controlling for clinical and demographic factors, analysis of covariance revealed a significant between-group difference for set-switching errors; planned contrasts revealed increased set-switching errors in URFOG relative to RFOG and PD control groups. Groups were not different in other cognitive domains. FOG severity was modestly associated with set-switching errors in RFOG but not URFOG. TUG performances while "on" were associated with set-switching errors in PD controls, and with focused attention in RFOG.

conclusionPD patients with dopa-unresponsive FOG are more prone to set-switching errors than those who respond to treatment. Furthermore, executive function appears relevant to FOG severity only in patients who show dopamine response. Together, these findings suggest disruption of a common dopamine-mediated pathway for FOG and ability to monitor rules while alternating cognitive processes. Consideration of dopa-response could be useful in characterizing cohorts and treating FOG in PD.

Indexed as

AgedAntiparkinson AgentsAttentionDopamineExecutive FunctionFemaleGait Disorders, NeurologicHumansMaleMiddle AgedNeuropsychological TestsParkinson DiseaseSeverity of Illness IndexTask Performance and AnalysisTime and Motion StudiesTreatment OutcomeAntiparkinson AgentsDopamineCognitionDopa-responseExecutive functionFreezing of gaitParkinson

Identifiers

PMID34695654
PMCPMC8633152
OpenAlexW3206862767

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.