Evidence map›Paper›PMID 34695646›Full record

ReviewCurrent opinion in microbiology2022

Animal models for dissecting Vibrio cholerae intestinal pathogenesis and immunity.

Brandon Sit, Bolutife Fakoya, Matthew K Waldor

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Microorganisms · 2026
    Article
  2. Article
  3. Mechanisms of bacterial host-to-host transmission.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Frontiers in medicine · 2023
    Review
  11. Article
  12. InactivatedJournal of microbiology and biotechnology · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brandon SitDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Bolutife FakoyaDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Matthew K WaldorDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, MA, USA; Howard Hughes Medical Institute, Bethesda, MD, USA. Electronic address: mwaldor@research.bwh.harvard.edu.
Brigham and Women's Hospital · US

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
NIAID NIH HHS R01 AI042347Wellcome Trust
6 · The paper itself

Abstract

The human diarrheal disease cholera is caused by the bacterium Vibrio cholerae. Efforts to develop animal models that closely mimic cholera to study the pathogenesis of this disease began >125 years ago. Here, we review currently used non-surgical, oral inoculation-based animal models for investigation of V. cholerae intestinal colonization and disease and highlight recent discoveries that have illuminated mechanisms of cholera pathogenesis and immunity, particularly in the area of how V. cholerae interacts with the gut microbiome to influence infection. The emergence of high-throughput tools for studies of pathogen-host interactions, along with continued advances in host genetic engineering and manipulation in animal models of V. cholerae will deepen understanding of cholera pathogenesis, uncovering knowledge important for control of this globally important bacterial pathogen.

Indexed as

CholeraGastrointestinal MicrobiomeVibrio choleraeAnimalsDisease Models, AnimalHost-Pathogen Interactions

Identifiers

PMID34695646
PMCPMC8792189
OpenAlexW3209319357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.