Evidence map›Paper›PMID 34695539›Full record

ArticleEnvironmental toxicology and pharmacology2021

Effect of E-cigarettes aerosol exposure during lactation in rats: Hormonal and biochemical aspects.

Nour A Al-Sawalha, Roba Bdeir, Aiman Sohaib, Marwan Saad, Tasneem Inghaimesh, Omar F Khabour, Karem H Alzoubi, Alan Shihadeh

Open access · greenAbstract read
In one paragraph

Article in Environmental toxicology and pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Nour A Al-SawalhaDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. Electronic address: nasawalha@just.edu.jo.
Roba BdeirFaculty of Pharmacy, Jadara University, Irbid, Jordan.
Aiman SohaibFaculty of Pharmacy, Jadara University, Irbid, Jordan.
Marwan SaadDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Tasneem InghaimeshDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Omar F KhabourFaculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Karem H AlzoubiDepartment of Pharmacy Practice and Pharmacotherapeutics, University of Sharjah, Sharjah, UAE; Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Alan ShihadehMechanical Engineering Department, American University of Beirut, Beirut 1107 2020, Lebanon; Center for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, VA, USA.
Jordan University of Science and Technology · JOJadara University · JOVirginia Commonwealth University · US

Funding

Project 4: Using a prospective cohort survey to test population-level predictions generated by Projects 1-3U54DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BRELAND, ALISON, EISSENBERG, THOMAS EVAN · 2018 to 2022
$20.8M
NIDA NIH HHS U54 DA036105
6 · The paper itself

Abstract

Electronic cigarettes (e-cigarettes) have been marketed as a less lethal substitute for smoking traditional cigarettes. This study aims to investigate the impact of e-cigarettes aerosol exposure on lactating dams and pups, whose dams were exposed. Lactating dams received fresh air (control) or e-cigarettes aerosol during lactation (day 4-21). Maternal exposure to e-cigarettes aerosol during lactation induced significant reduction (P < 0.0001) in the fat content of the milk and serum Leptin level (P < 0.005) compared to control dams. Furthermore, pups whose dams were exposed to e-cigarettes during lactation showed an increased level of glucose, thyroxine and decreased level of insulin. The exposure to e-cigarettes aerosol during lactation altered the composition of milk as well as the hormonal and biochemical profile in dams and pups. This result, if observed in women using e-cigarettes, suggests that e-cigarettes' use during lactation may have consequences on the milk production and hormonal and biochemical profile in breastfeeding mothers and nursing babies.

Indexed as

Electronic Nicotine Delivery SystemsLactationAdministration, InhalationAerosolsAnimalsBlood GlucoseFatsFemaleInsulinLeptinMaleMaternal ExposureMilkRatsRats, WistarThyroxineAerosolsBlood GlucoseFatsInsulinLeptinThyroxineBreastfeedingElectronic cigarettesGlucoseLactationLeptinMilk

Identifiers

PMID34695539
PMCPMC8957699
OpenAlexW3209343692

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.