Evidence map›Paper›PMID 34695402›Full record

ArticleAmerican journal of ophthalmology2022

Longitudinal Changes in Scotopic and Mesopic Macular Function as Assessed with Microperimetry in Patients With Stargardt Disease: SMART Study Report No. 2.

Xiangrong Kong, Mohamed Ibrahim-Ahmed, Millena G Bittencourt, Rupert W Strauss, David G Birch, Artur V Cideciyan, Ann-Margaret Ervin, Alexander Ho, Janet S Sunness, Isabelle S Audo and 7 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 6 countries.

Xiangrong KongWilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA; Department of Biostatistics (X.K.), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA; Department of Epidemiology (X.K., A.-M.E.), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA; Department of Health Behavior and Society (X.K.), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: xkong4@jhu.edu.
Mohamed Ibrahim-AhmedOcular Imaging Research and Reading Center (M.I.-A.), Sunnyvale, California, USA.
Millena G BittencourtWilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA.
Rupert W StraussMoorfields Eye Hospital and UCL Institute of Ophthalmology (R.W.S., M.M.), London, UK; Department of Ophthalmology (R.W.S.), Kepler University Clinic, Linz, Linz, Austria; Department of Ophthalmology (R.W.S.), Medical University of Graz, Graz, Austria.
David G BirchRetina Foundation of the Southwest (D.G.B.), Dallas, Texas, USA.
Artur V CideciyanScheie Eye Institute (A.V.C.), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ann-Margaret ErvinWilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA; Department of Epidemiology (X.K., A.-M.E.), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Alexander HoDoheny Image Reading Center (A.H., S.V.S., M.S.I.), Los Angeles, California, USA.
Janet S SunnessGreater Baltimore Medical Center (J.S.S.), Baltimore, Maryland, USA.
Isabelle S AudoCHNO des Quinze-Vingts (I.S.A.), DHU Sight Restore, INSERM-DHOS CIC 1423, Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision, Paris, France.
Michel MichaelidesMoorfields Eye Hospital and UCL Institute of Ophthalmology (R.W.S., M.M.), London, UK.
Eberhart ZrennerUniversitäts-Augenklinik (E.Z.), University of Tübingen, Tübingen, Germany.
SriniVas SaddaDoheny Image Reading Center (A.H., S.V.S., M.S.I.), Los Angeles, California, USA.
Michael S IpDoheny Image Reading Center (A.H., S.V.S., M.S.I.), Los Angeles, California, USA.
Sheila WestWilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA.
Hendrik P N SchollWilmer Eye Institute at the Johns Hopkins University (X.K., M.G.B., A.-M.E., S.W., H.P.N.S.), Baltimore, Maryland, USA; Institute of Molecular and Clinical Ophthalmology Basel (IOB) (H.P.N.S.), Basel, Switzerland; Department of Ophthalmology (H.P.N.S.), University of Basel, Basel, Switzerland.
SMART Study Group
Johns Hopkins University · USDoheny Eye Institute · USMoorfields Eye Hospital NHS Foundation Trust · GBCentre National de la Recherche Scientifique · FRGreater Baltimore Medical Center · USOcular Surface Center · USPenn Presbyterian Medical Center · USRetina Foundation of the Southwest · USUniversitäts-Augenklinik Bonn · DE

Funding

Structure-Function Relationships in Stargardt Disease.R21EY032955 · NEI · JOHNS HOPKINS UNIVERSITY · PI KONG, XIANGRONG · 2021 to 2022
$444k
NEI NIH HHS R21 EY032955Wellcome Trust
6 · The paper itself

Abstract

purposeTo estimate and compare cross-sectional scotopic versus mesopic macular sensitivity losses measured by microperimetry, and to report and compare the longitudinal rates of scotopic and mesopic macular sensitivity losses in ABCA4 gene-associated Stargardt disease (STGD1).

designThis was a multicenter prospective cohort study.

methodsParticipants comprised 127 molecularly confirmed STGD1 patients enrolled from 6 centers in the United States and Europe and followed up every 6 months for up to 2 years. The Nidek MP-1S device was used to measure macular sensitivities of the central 20° under mesopic and scotopic conditions. The mean deviations (MD) from normal for mesopic macular sensitivity for the fovea (within 2° eccentricity) and extrafovea (4°-10° eccentricity), and the MD for scotopic sensitivity for the extrafovea, were calculated. Linear mixed effects models were used to estimate mesopic and scotopic changes. Main outcome measures were baseline mesopic mean deviation (mMD) and scotopic MD (sMD) and rates of longitudinal changes in the mMDs and sMD.

resultsAt baseline, all eyes had larger sMD, and the difference between extrafoveal sMD and mMD was 10.7 dB (P < .001). Longitudinally, all eyes showed a statistically significant worsening trend: the rates of foveal mMD and extrafoveal mMD and sMD changes were 0.72 (95% CI = 0.37-1.07), 0.86 (95% CI = 0.58-1.14), and 1.12 (95% CI = 0.66-1.57) dB per year, respectively.

conclusionsIn STGD1, in extrafovea, loss of scotopic macular function preceded and was faster than the loss of mesopic macular function. Scotopic and mesopic macular sensitivities using microperimetry provide alternative visual function outcomes for STGD1 treatment trials.

Indexed as

Macular DegenerationVisual Field TestsATP-Binding Cassette TransportersCross-Sectional StudiesFovea CentralisHumansProspective StudiesStargardt DiseaseTomography, Optical CoherenceVisual AcuityABCA4 protein, humanATP-Binding Cassette Transporters

Identifiers

PMID34695402
PMCPMC8957498
OpenAlexW3208614557

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.