Evidence map›Paper›PMID 34695361›Full record

ArticleThe journal of physical chemistry. B2021

Investigation of the p

Andrew J Veenis, Pengfei Li, Alexander V Soudackov, Sharon Hammes-Schiffer, Philip C Bevilacqua

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Andrew J Veenis
Pengfei LiDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-2572-5935
Alexander V SoudackovDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-9581-8494
Sharon Hammes-SchifferDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-3782-6995
Philip C BevilacquaORCID 0000-0001-8074-3434
Pennsylvania State University · USYale University · USLoyola University Chicago · US

Funding

RNA folding and catalysis at the interface of biophysics and genomicsR35GM127064 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PHILIP C BEVILACQUA · 2018 to 2026
$3.4M
Coupled Protons and Electrons in Biological SystemsR35GM139449 · NIGMS · YALE UNIVERSITY · PI HAMMES-SCHIFFER, SHARON · 2021 to 2025
$2.1M
NIGMS NIH HHS R35 GM127064NIGMS NIH HHS R35 GM139449
6 · The paper itself

Abstract

Small ribozymes cleave their RNA phosphodiester backbone by catalyzing a transphosphorylation reaction wherein a specific O2' functions as the nucleophile. While deprotonation of this alcohol through its acidification would increase its nucleophilicity, little is known about the p

Indexed as

RNA, CatalyticCatalytic DomainIonsMolecular Dynamics SimulationNucleic Acid Conformationhairpin ribozymeIonsRNA, Catalytic

Identifiers

PMID34695361
PMCPMC8760728
OpenAlexW3208819826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.