ArticleJournal of the American Geriatrics Society2022
Association of healthy lifestyle and all-cause mortality according to medication burden.
Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Examining Healthy Lifestyles as a Mediator of the Association Between Socially Determined Vulnerabilities and Incident Heart Failure.Circulation. Cardiovascular quality and outcomes · 2025Article
- Objectively-Measured Sedentary Time and Self-Reported Prescription Medication Use Among Adults: A Pilot Study.Pharmacy (Basel, Switzerland) · 2024Article
- Association between tooth loss and depression mediated by lifestyle and Inflammation- a cross-sectional investigation.BMC public health · 2024Article
- An analysis of protective health behavior and polypharmacy among older patients: a nationwide cohort study.BMC geriatrics · 2024Article
- Health impacts of lifestyle and ambient air pollution patterns on all-cause mortality: a UK Biobank cohort study.BMC public health · 2024Article
- Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis.Alzheimer's research & therapy · 2024Article
- Association of Healthy Lifestyle and Incident Polypharmacy.The American journal of medicine · 2024Article
- Emerging healthy lifestyle factors and all-cause mortality among people with metabolic syndrome and metabolic syndrome-like characteristics in NHANES.Journal of translational medicine · 2023Article
- Polypharmacy, Unintended Consequences, and Impact of Lifestyle Medicine.American journal of lifestyle medicineReview
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7 authors.
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Abstract
backgroundHealthy lifestyle is associated with reduced all-cause mortality, but it is not known whether this association persists for individuals with high medication burden. We examined the association between healthy lifestyle behaviors and all-cause mortality across different degrees of polypharmacy.
methodsThis was a secondary analysis of 20,417 adults aged ≥45 years from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study. The primary exposure was healthy lifestyle (adherence to Mediterranean diet, physical activity, smoking abstinence, sedentary behavior avoidance, and composite healthy behavior score [HBS]). The primary outcome was all-cause mortality. Strata of medication burden were based on the number of medications taken (no polypharmacy: 0-4, polypharmacy: 5-9, hyperpolypharmacy: ≥10). We used Cox proportional hazards regression models to examine the association between healthy lifestyle behaviors and mortality within each medication burden stratum and examined for interactions with age.
resultsThe healthiest category of each lifestyle behavior, except sedentary behavior avoidance among the hyperpolypharmacy group, was associated with lower all-cause mortality (hazard ratio [HR]) regardless of medication burden: Mediterranean diet (no polypharmacy: HR 0.77, polypharmacy: HR 0.78, hyperpolypharmacy: HR 0.85), physical activity (no polypharmacy: HR 0.87, polypharmacy: HR 0.82, hyperpolypharmacy: HR 0.79), smoking abstinence (no polypharmacy: HR 0.40, polypharmacy: HR 0.45, hyperpolypharmacy: HR 0.52), and sedentary behavior avoidance (no polypharmacy: HR 0.88, polypharmacy: HR 0.86, hyperpolypharmacy: HR 0.95). Higher HBS was inversely associated with all-cause mortality within each medication burden stratum (no polypharmacy: HR 0.52, polypharmacy: HR 0.55, hyperpolypharmacy: HR 0.69). Although there was an interaction with age among those with no polypharmacy and those with polypharmacy, point estimates for HBS followed a graded pattern whereby higher HBS was incrementally associated with improved mortality across all age strata.
conclusionGreater adherence to a healthy lifestyle was associated with lower all-cause mortality irrespective of medication burden and age.
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