ArticleEuropean journal of preventive cardiology2021
Long-term cumulative blood pressure in young adults and incident heart failure, coronary heart disease, stroke, and cardiovascular disease: The CARDIA study.
Article in European journal of preventive cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 68 citations in OpenAlex.
- Effects of salt substitution on cumulative blood pressure: a secondary analysis of the SSaSS.European journal of epidemiology · 2025Trial
- Effects of cumulative systolic blood pressure on arterial stiffness: a cross-sectional study based on a community in northern China with 16 years of follow-up.Journal of human hypertension · 2026Article
- First Comparative Evaluation of TyG-ABSI Versus Traditional TyG-Related Indices for Cardiovascular Disease and Mortality Prediction in Hypertensive Patients: TyG-ABSI Versus Traditional TyG-Related Indices.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Repeated Health Screening Measures and Incident Ischemic Stroke: Evidence From a Korean Population Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Socioeconomic Disadvantage, John Henryism, and Incident Heart Failure in the Jackson Heart Study.Circulation. Population health and outcomes · 2026Article
- Association of organ dysfunction trajectories and major adverse cardiovascular events using clinical obesity in UK Biobank.Frontiers in endocrinology · 2026Article
- Time-averaged cumulative pulse pressure in midlife and incident atrial fibrillation: the atherosclerosis risk in communities study.Journal of human hypertension · 2026Article
- Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population.Annals of medicine · 2025Article
- Cumulative blood pressure exposure and global and regional cardiac structure and function: the MESA study.European journal of preventive cardiology · 2025Observational
- Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Trastuzumab therapy and new-onset hypertension in adolescents and young adults with breast cancer.Breast cancer research and treatment · 2025Article
- Blood Pressure Responses During Exercise Were Associated With Average Home Blood Pressure and Home Blood Pressure Variability: The Electronic Framingham Heart Study.Journal of the American Heart Association · 2025Article
- Effects of substituting TV-watching time with physical activities or sleep on incident major depression. Results from the lifelines cohort study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Determinants of Medication Non-Adherence among Productive-Aged Hypertensive Patients in Indonesia: A Secondary Data Analysis of Basic Health Research Database 2018.Iranian journal of public health · 2025Article
- Comparison of the cumulative exposure to four measures of blood pressure for predicting cardiovascular disease risk in the Chinese Uyghurs.BMC public health · 2025Article
- Tracking of blood pressure levels from childhood.Pediatric nephrology (Berlin, Germany) · 2025Review
- Effects of key physiological parameters on cardiovascular disease and osteoporosis risk in perimenopausal and postmenopausal women.Scientific reports · 2025Article
- Predicting new-onset stroke with machine learning: development of a model integrating traditional Chinese and western medicine.Frontiers in pharmacology · 2025Article
- Blood Pressure Trajectories During Young Adulthood and Cardiovascular Events in Later Life.American journal of hypertension · 2024Article
- Short- and Long-Term Effects of Inhaled Ultrafine Particles on Blood Pressure: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
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Authors and funding
16 authors at 10 institutions in 1 country.
Funding
Abstract
aimsCumulative blood pressure (BP) is a measure that incorporates the severity and duration of BP exposure. The prognostic significance of cumulative BP in young adults for cardiovascular diseases (CVDs) in comparison to BP severity alone is, however, unclear. METHODS AND
resultsWe investigated 3667 Coronary Artery Risk Development in Young Adults participants who attended six visits over 15 years (year-0 (1985-1986), year-2, year-5, year-7, year-l0, and year-15 exams). Cumulative BP was calculated as the area under the curve (mmHg × years) from year 0 through year 15. Cox models assessed the association between cumulative BP (year 0 through year 15), current BP (year 15), and BP change (year 0 and year 15) and CVD outcomes. Mean (standard deviation) age at year 15 was 40.2 (3.6) years, 44.1% were men, and 44.1% were African-American. Over a median follow-up of 16 years, there were 47 heart failure (HF), 103 coronary heart disease (CHD), 71 stroke, and 191 CVD events. Cumulative systolic BP (SBP) was associated with HF (hazard ratio (HR) = 2.14 (1.58-2.90)), CHD (HR = 1.49 (1.19-1.87)), stroke (HR = 1.81 (1.38-2.37)), and CVD (HR = 1.73 (1.47-2.05)). For CVD, the C-statistic for SBP (year 15) was 0.69 (0.65-0.73) and change in C-statistic with the inclusion of SBP change and cumulative SBP was 0.60 (0.56-0.65) and 0.72 (0.69-0.76), respectively. For CVD, using year-15 SBP as a reference, the net reclassification index (NRI) for cumulative SBP was 0.40 (p < 0.0001) and the NRI for SBP change was 0.22 (p = 0.001).
conclusionsCumulative BP in young adults was associated with the subsequent risk of HF, CHD, stroke, and CVD. Cumulative BP provided incremental prognostic value and improved risk reclassification for CVD, when compared to single BP assessments or changes in BP.
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