Evidence map›Paper›PMID 34694903›Full record

ArticleJournal of bacteriology2022

Structure of the Streptococcus pyogenes NAD

Jorge J Velarde, Alessandro Piai, Ian J Lichtenstein, Nicola N Lynskey, James J Chou, Michael R Wessels

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Immunomodulating Enzymes fromMicroorganisms · 2024
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jorge J VelardeDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Alessandro PiaiDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Ian J LichtensteinDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Nicola N LynskeyDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
James J ChouDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Michael R WesselsDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Harvard University · USBoston Children's Hospital · US

Funding

Pain and Neuro-immune Signaling in S. pyogenes pathogenesisR01AI130019 · NIAID · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG, WESSELS, MICHAEL R · 2017 to 2021
$3.2M
Structure and Function Studies of LL-37 Binding to CsrS of Group A StreptococcusK08AI112823 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI VELARDE, JORGE J · 2016 to 2020
$939k
NIAID NIH HHS K08 AI112823NIAID NIH HHS K08-AI112823NIAID NIH HHS R01 AI130019NIAID NIH HHS R01-AI130019
6 · The paper itself

Abstract

The emergence and continued dominance of a Streptococcus pyogenes (group A Streptococcus, GAS) M1T1 clonal group is temporally correlated with acquisition of genomic sequences that confer high level expression of cotoxins streptolysin O (SLO) and NAD

Indexed as

Amino Acid SubstitutionBacterial AdhesionBacterial ProteinsBacterial ToxinsCell LineHumansKeratinocytesModels, MolecularNAD+ NucleosidaseOropharynxProtein BindingProtein ConformationProtein DomainsProtein TransportStreptococcus pyogenesStreptolysinsBacterial ProteinsBacterial ToxinsNAD+ Nucleosidasestreptolysin OStreptolysinscell bindingNADaseNMR spectroscopynuclear magnetic resonanceStreptococcus pyogenestoxintoxins

Identifiers

PMID34694903
PMCPMC8765395
OpenAlexW3211013855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.