Evidence map›Paper›PMID 34694882›Full record

ArticleAntimicrobial agents and chemotherapy2022

Exploration of the Pharmacodynamics for Pseudomonas aeruginosa Biofilm Eradication by Tobramycin.

Devin Sindeldecker, Shaurya Prakash, Paul Stoodley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Devin SindeldeckerDepartment of Microbial Infection and Immunity, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.ORCID 0000-0002-9428-2234
Shaurya PrakashDepartment of Mechanical & Aerospace Engineering, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.
Paul StoodleyDepartment of Microbial Infection and Immunity, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.
The Ohio State University · USUniversity of Southampton · GB

Funding

The role of Staphylococcus aureus aggregate formation in establishing biofilms in chronic orthopaedic periprosthetic joint infection.R01GM124436 · NIGMS · OHIO STATE UNIVERSITY · PI STOODLEY, PAUL · 2018 to 2021
$2.1M
Biophysical-based approach for controlling blood vessel structure and functionR01HL141941 · NHLBI · OHIO STATE UNIVERSITY · PI CASTRO, CARLOS E., PRAKASH, SHAURYA · 2018 to 2021
$2.0M
NHLBI NIH HHS R01 HL141941NIGMS NIH HHS R01 GM124436
6 · The paper itself

Abstract

Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen which is involved in numerous infections. It is of growing concern within the field of antibiotic resistance and tolerance and often exhibits multidrug resistance. Previous studies have shown the emergence of antibiotic-resistant and -tolerant variants within the zone of clearance of a biofilm lawn after exposure to aminoglycosides. As concerning as the tolerant variant emergence is, there was also a zone of killing (ZOK) immediately surrounding the antibiotic source from which no detectable bacteria emerged or were cultured. In this study, the ZOK was analyzed using both

Indexed as

Pseudomonas InfectionsTobramycinAminoglycosidesAnti-Bacterial AgentsBiofilmsHumansPseudomonas aeruginosaAminoglycosidesAnti-Bacterial AgentsTobramycinbiofilmspharmacodynamicsPseudomonas aeruginosatobramycin

Identifiers

PMID34694882
PMCPMC8765403
OpenAlexW3209589819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.