Evidence map›Paper›PMID 34694871›Full record

ArticleAntimicrobial agents and chemotherapy2022

Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing.

Mariko Kanai, Tomas Yeo, Victor Asua, Philip J Rosenthal, David A Fidock, Sachel Mok

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Double Mutations inbioRxiv : the preprint server for biology · 2026
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  11. Fast-Killing Tyrosine Amide ((ACS infectious diseases · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mariko KanaiDepartment of Microbiology and Immunology, Columbia Universitygrid.21729.3fgrid.239585.0 Irving Medical Center, New York, New York, USA.ORCID 0000-0002-7767-2046
Tomas YeoDepartment of Microbiology and Immunology, Columbia Universitygrid.21729.3fgrid.239585.0 Irving Medical Center, New York, New York, USA.ORCID 0000-0003-2923-6060
Victor AsuaInfectious Disease Research Collaboration, Kampala, Uganda.ORCID 0000-0002-0489-4692
Philip J RosenthalDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0002-7953-7622
David A FidockDepartment of Microbiology and Immunology, Columbia Universitygrid.21729.3fgrid.239585.0 Irving Medical Center, New York, New York, USA.ORCID 0000-0001-6753-8938
Sachel MokDepartment of Microbiology and Immunology, Columbia Universitygrid.21729.3fgrid.239585.0 Irving Medical Center, New York, New York, USA.ORCID 0000-0002-9605-0154
Columbia University Irving Medical Center · USInfectious Diseases Research Collaboration · UGUniversity of California, San Francisco · US

Funding

Role of pfcrt in chloroquine resistance in P. falciparumR01AI050234 · NIAID · YESHIVA UNIVERSITY · PI FIDOCK, DAVID A · 2001 to 2015
$5.7M
Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4M
Defining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4M
Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparumR01AI124678 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2016 to 2026
$4.3M
NIAID NIH HHS R01 AI050234NIAID NIH HHS R01 AI109023NIAID NIH HHS R01 AI124678NIAID NIH HHS R37 AI050234
6 · The paper itself

Abstract

Research efforts to combat antimalarial drug resistance rely on quick, robust, and sensitive methods to genetically characterize Plasmodium falciparum parasites. We developed a single-nucleotide polymorphism (SNP)-based genotyping method that can assess 33 drug resistance-conferring SNPs in

Indexed as

AntimalarialsMalaria, FalciparumDrug ResistanceGenotypeHumansMicrosatellite RepeatsPlasmodium falciparumProtozoan ProteinsAntimalarialsProtozoan Proteinsdrug resistancegenotypingmalariamicrosatellitesPlasmodium falciparum

Identifiers

PMID34694871
PMCPMC8765236
OpenAlexW3208818600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.