Evidence map›Paper›PMID 34694720›Full record

ArticleIET nanobiotechnology2021

One-pot synthesis chlorin e6 nano-precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment.

Zhongxing Miao, Yujie Wang, Shengjie Li, Min Zhang, Meng Xu

Abstract read
In one paragraph

Article in IET nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhongxing MiaoDepartment of Gastroenterology Surgery, Dalian Municipal Central Hospital, Dalian, Liaoning, China.
Yujie WangDepartment of Gastroenterology Surgery, Dalian Municipal Central Hospital, Dalian, Liaoning, China.
Shengjie LiDepartment of Gastroenterology Surgery, Dalian Municipal Central Hospital, Dalian, Liaoning, China.
Min ZhangDepartment of Department of Anorectal Surgery, Dalian Municipal Central Hospital, Dalian, Liaoning, China.
Meng XuDepartment of Department of Anorectal Surgery, Dalian Municipal Central Hospital, Dalian, Liaoning, China.ORCID https://orcid.org/0000-0002-9470-9410

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one-pot method to prepare chlorin e6 (Ce6) nano-precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loading of Ce6 NPs was around 81% and showed acceptable stability, high biocompatibility as well as effective reactive oxygen species (ROS) generation capability. As a result, the Ce6 NPs can produce significantly elevated ROS upon laser irradiations and achieved better anticancer benefits than free Ce6.

Indexed as

Colorectal NeoplasmsNanoparticlesPhotochemotherapyPorphyrinsCell Line, TumorChlorophyllidesHumansPhotosensitizing AgentsChlorophyllidesPhotosensitizing AgentsphytochlorinPorphyrins

Identifiers

PMID34694720
PMCPMC8675780

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.