Evidence map›Paper›PMID 34694717›Full record

ArticleIET nanobiotechnology2021

Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin-induced diabetic nephropathy rats.

Ragavee Ambalavanan, Arul Daniel John, Asha Devi Selvaraj

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IET nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Metabolites · 2022
    Article
  5. Current Strategies and Potential Prospects for Nanoparticle-Mediated Treatment of Diabetic Nephropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ragavee AmbalavananDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
Arul Daniel JohnDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
Asha Devi SelvarajDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.ORCID https://orcid.org/0000-0002-0005-5162
Vellore Institute of Technology University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC-loaded PLA Nanoparticles (TC-PLA NPs) on streptozotocin (STZ)-induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC-PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy.

Indexed as

Diabetes MellitusDiabetic NephropathiesNanoparticlesTinosporaAnimalsPlant ExtractsPolyestersRatsStreptozocinPlant ExtractsPolyesterspoly(lactide)Streptozocin

Identifiers

PMID34694717
PMCPMC8675778
OpenAlexW3137389108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.