Evidence map›Paper›PMID 34694654›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Activation of the calcium sensing receptor increases claudin-14 expression via a PLC -p38-Sp1 pathway.

Justin J Lee, Jawad Alzamil, Saba Rehman, Wanling Pan, Henrik Dimke, R Todd Alexander

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Magnesium biology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  4. Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024
    Review
  5. The role of claudins in homeostasis.Nature reviews. Nephrology · 2023
    Review
  6. Review
  7. Activation of the calcium sensing receptor increases claudin-14 expression via a PLC -p38-Sp1 pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Justin J LeeDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Jawad AlzamilDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Saba RehmanDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Wanling PanDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Henrik DimkeDepartment of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
R Todd AlexanderDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-7396-7894
University of Alberta · CAUniversity of Southern Denmark · DK

Funding

CIHR MOP 136891
6 · The paper itself

Abstract

Activation of the basolateral calcium sensing receptor (CaSR) in the renal tubular thick ascending limb (TAL) increases claudin-14 expression, which reduces paracellular calcium (Ca

Indexed as

AnimalsCalciumClaudinsHEK293 CellsHeLa CellsHumansKidney TubulesMiceMice, Inbred C57BLRatsReceptors, Calcium-SensingSp1 Transcription FactorType C PhospholipasesCalciumclaudin 14ClaudinsReceptors, Calcium-SensingSp1 Transcription FactorType C Phospholipasescalcium homeostasisclaudinsurine calcium excretion

Identifiers

PMID34694654
PMCPMC9297942
OpenAlexW3208597076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.