Evidence map›Paper›PMID 34694549›Full record

ReviewMolecular biology reports2022

The role of TRPV channels in osteoporosis.

Na Liu, Weiwei Lu, Xiaolin Dai, Xiaowen Qu, Chongtao Zhu

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07783295 (Evaluation of Bone Turnover Biomarkers, CB2 and TRPV1 Polymorphisms as Potential Preventive Data in Osteoporosis and Perception of Improvement in Quality of Life in Women With Chronic Pain Treated With Medicinal Cannabis), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07783295 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Bone Turnover Biomarkers, CB2 and TRPV1 Polymorphisms as Potential Preventive Data in Osteoporosis and Perception of Improvement in Quality of Life in Women With Chronic Pain Treated With Medicinal Cannabis

TypeinterventionalSponsorAssociação Pan-Americana Multidisciplinar de EndocanabinologiaRan2026 to 2027Enrolled80ConditionsChronic Pain, Fibromyalgia, Osteoporosis, Orofacial PainArmsFull-Spectrum Cannabis Extract 5:1 (CBD:THC)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Review
  3. Mechanosignaling in Osteoporosis: When Cells Feel the Force.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Role of TRP Channels in Cancer-Induced Bone Pain.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Impact ofNutrients · 2024
    Article
  10. Article
  11. Review
  12. Calcium sensing and signaling are impaired in the lumbar spine of a rat model of congenital kyphosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Na Liu *Department of Anesthesiology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, China.
Weiwei Lu *Medical School, Kunming University of Science and Technology, Kunming, 650500, China.
Xiaolin DaiMedical School, Kunming University of Science and Technology, Kunming, 650500, China.
Xiaowen QuLaser Medical Center, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 159 JinBi Road, Kunming, 650032, China.
Chongtao ZhuLaser Medical Center, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 159 JinBi Road, Kunming, 650032, China. surgeon036tougao@163.com.
Kunming University of Science and Technology · CNFirst People's Hospital of Yunnan Province · CN

Funding

application base project of yunnan science and technology department 2019FB097national key research and development project 2017YFB0403801the joint special program of science and technology department of yunnan province and kunming medical university for applied basic research 2019FE001(-111)yunnan fundamental research key projects 202101AS070046yunnan health training project of high level talents D-2018005yunnan high-level scientific and technological talent platform plan 202105AC160064
6 · The paper itself

Abstract

As the world's population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca

Indexed as

Disease SusceptibilityAnimalsBone and BonesCalciumCell DifferentiationGene Expression RegulationHumansMultigene FamilyOsteoblastsOsteoporosisSignal TransductionTransient Receptor Potential ChannelsCalciumTransient Receptor Potential ChannelsCa2+OsteoblastsOsteoclastsOsteoporosisTRPV

Identifiers

PMID34694549
OpenAlexW3209993550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.