Evidence map›Paper›PMID 34694528›Full record

ArticleMolecular imaging and biology2022

PET Imaging of VLA-4 in a New BRAF

Michael C Bellavia, Lea Nyiranshuti, Joseph D Latoche, Khanh-Van Ho, Ronald J Fecek, Jennifer L Taylor, Kathryn E Day, Shubhanchi Nigam, Michael Pun, Fabio Gallazzi and 4 more

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Article
  6. An Overview of In Vitro Assays ofDiagnostics (Basel, Switzerland) · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Michael C Bellavia *Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Lea Nyiranshuti *Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Joseph D LatocheDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Khanh-Van HoDepartment of Chemistry, University of Missouri, Columbia, MO, 65211, USA.
Ronald J FecekDepartment of Dermatology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Jennifer L TaylorDepartment of Dermatology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Kathryn E DayDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Shubhanchi NigamDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Michael PunDepartment of Chemistry, University of Missouri, Columbia, MO, 65211, USA.
Fabio GallazziDepartment of Chemistry, University of Missouri, Columbia, MO, 65211, USA.
Robert S EdingerDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Walter J StorkusDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Ravi B PatelDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15213, USA. patelr20@upmc.edu.ORCID 0000-0002-8328-746X
Carolyn J AndersonDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15213, USA. carolyn.j.anderson@missouri.edu.
University of Pittsburgh · USUniversity of Missouri · USUniversity of California, Los Angeles · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Image guided immunotherapy and targeted radionuclide therapy of metastatic melanomaR01CA214018 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANDERSON, CAROLYN J. · 2017 to 2021
$2.3M
Utilization of molecular targeted radionuclides to prime immune responses at local and distant metastatic tumor sitesK08CA241319 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI PATEL, RAVI BHASKER · 2019 to 2023
$629k
World Molecular Imaging Congress. The WMIC provides a platform for a wide array of scientists and clinicians with diverse areas of expertise to interact, present, and discuss cutting-edge advances inR13EB033695 · NIBIB · WORLD MOLECULAR IMAGING SOCIETY · PI ANDERSON, CAROLYN J. · 2022 to 2022
$14k
NCI NIH HHS K08 CA241319NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA214018NIBIB NIH HHS R13 EB033695
6 · The paper itself

Abstract

purposeDespite unprecedented responses to immune checkpoint inhibitors and targeted therapy in melanoma, a major subset of patients progresses and have few effective salvage options. We have previously demonstrated robust, selective uptake of the peptidomimetic LLP2A labeled with Cu-64 ([ PROCEDURES: BPR cells were transduced with α

results[

conclusions[

Indexed as

Integrin alpha4beta1MelanomaAnimalsCell Line, TumorCopper RadioisotopesDisease Models, AnimalHumansMicePositron-Emission TomographyPositron Emission Tomography Computed TomographyProspective StudiesProto-Oncogene Proteins B-rafTissue DistributionBRAF protein, humanCopper-64Copper RadioisotopesIntegrin alpha4beta1Proto-Oncogene Proteins B-rafBRAF mutant melanomaCD49dLLP2APET imagingTheranosticVLA-4

Identifiers

PMID34694528
PMCPMC9183947
OpenAlexW3210719932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.