Evidence map›Paper›PMID 34694495›Full record

ArticleClinical oral investigations2022

Enhanced osteoinductive capacity of poly(lactic-co-glycolic) acid and biphasic ceramic scaffolds by embedding simvastatin.

Mariane B Sordi, Raissa B Curtarelli, Iara F Mantovani, Anderson C Moreira, Celso P Fernandes, Ariadne C C Cruz, Ricardo S Magini

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Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mariane B SordiDepartment of Dentistry, Center for Research On Dental Implants (CEPID), Federal University of Santa Catarina, Florianopolis, Brazil.
Raissa B CurtarelliDepartment of Dentistry, Center for Research On Dental Implants (CEPID), Federal University of Santa Catarina, Florianopolis, Brazil.
Iara F MantovaniDepartment of Mechanical Engineering, Laboratory of Porous Media and Thermophysical Properties (LMPT), Federal University of Santa Catarina, Florianopolis, Brazil.
Anderson C MoreiraDepartment of Mechanical Engineering, Laboratory of Porous Media and Thermophysical Properties (LMPT), Federal University of Santa Catarina, Florianopolis, Brazil.
Celso P FernandesDepartment of Mechanical Engineering, Laboratory of Porous Media and Thermophysical Properties (LMPT), Federal University of Santa Catarina, Florianopolis, Brazil.
Ariadne C C CruzDepartment of Dentistry, Center for Research On Dental Implants (CEPID), Federal University of Santa Catarina, Florianopolis, Brazil. ariadne.cruz@ufsc.br.
Ricardo S MaginiDepartment of Mechanical Engineering, Laboratory of Porous Media and Thermophysical Properties (LMPT), Federal University of Santa Catarina, Florianopolis, Brazil.
Universidade Federal de Santa Catarina · BR

Funding

International Team for Implantology 1113_2015
6 · The paper itself

Abstract

objectivesThis study evaluated the effect of embedding simvastatin (SIM) on the osteoinductive capacity of PLGA + HA/βTCP scaffolds in stem cells from human exfoliated deciduous teeth (SHED). MATERIALS AND

methodsScaffolds were produced by PLGA solvent dissolution, addition of HA/βTCP, solvent evaporation, and leaching of sucrose particles to impart porosity. Biphasic ceramic particles (70% HA/30% βTCP) were added to the PLGA in a 1:1 (w:w) ratio. Scaffolds with SIM received 1% (w:w) of this medication. Scaffolds were synthesized in a disc-shape and sterilized by ethylene oxide. The experimental groups were (G1) PLGA + HA/βTCP and (G2) PLGA + HA/βTCP + SIM in non-osteogenic culture medium, while (G3) SHED and (G4) MC3T3-E1 in osteogenic culture medium were the positive control groups. The release profile of SIM from scaffolds was evaluated. DNA quantification assay, alkaline phosphatase activity, osteocalcin and osteonectin proteins, extracellular calcium detection, von Kossa staining, and X-ray microtomography were performed to assess the capacity of scaffolds to induce the osteogenic differentiation of SHED.

resultsThe release profile of SIM followed a non-liner sustained-release rate, reaching about 40% of drug release at day 28. Additionally, G2 promoted the highest osteogenic differentiation of SHED, even when compared to the positive control groups.

conclusionsIn summary, the osteoinductive capacity of poly(lactic-co-glycolic) acid and biphasic ceramic scaffolds was expressively enhanced by embedding simvastatin. CLINICAL RELEVANCE: Bone regeneration is still a limiting factor in the success of several approaches to oral and maxillofacial surgeries, though tissue engineering using mesenchymal stem cells, scaffolds, and osteoinductive mediators might collaborate to this topic.

Indexed as

OsteogenesisSimvastatinCell DifferentiationCeramicsGlycolsHumansPolylactic Acid-Polyglycolic Acid CopolymerTissue EngineeringTissue ScaffoldsGlycolsPolylactic Acid-Polyglycolic Acid CopolymerSimvastatinBone regenerationMesenchymal stem cellsOsteogenic differentiationScaffoldsSimvastatin

Identifiers

PMID34694495
OpenAlexW3208877270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.