Observational studyThe Journal of clinical endocrinology and metabolism2022
Association Between HbA1c Levels on Adverse Pregnancy Outcomes During Pregnancy in Patients With Type 1 Diabetes.
Observational study in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- HbA1c improvement in pregnant women with type 1 diabetes using the CamAPS FX automated insulin delivery (AID) system: Clinical and economic outcomes.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Risk factors for unplanned cesarean delivery among pregnant individuals with pre-existing diabetes.Pregnancy (Hoboken, N.J.) · 2026Article
- Glycaemic Control in Women With Type 1 Diabetes and Preeclampsia Risk: A Nationwide Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Nursing Care in Obstetrics and Breastfeeding Practices in Gestational Diabetic Mothers in China: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2025Review
- Association of Early Pregnancy Inflammatory Indices with Preterm Birth and Perinatal Outcomes in Pregnancies with Pregestational Diabetes.Journal of clinical medicine · 2025Article
- Glycosylated Hemoglobin Levels in the Third Trimester for Predicting Adverse Pregnancy and Neonatal Outcomes in Women with Pre-Gestational Diabetes: A Multi-Center Retrospective Cohort Study in South Korea.Journal of clinical medicine · 2025Article
- Reference interval for glycated hemoglobin (HbA1c) in non-pregnant, non-diabetic women in Ethiopia: a cross-sectional study.The Pan African medical journal · 2025Article
- Article
- Differential Effects of First and Third Trimester HbA1c Levels on Neonatal Weight and Placental Mediation in Type 1 Diabetes.Frontiers in endocrinology · 2025Observational
- All Children Deserve to Be Safe, Mothers Too: Evidence and Rationale Supporting Continuous Glucose Monitoring Use in Gestational Diabetes Within the Medicaid Population.Journal of diabetes science and technology · 2024Review
- Glycemic control assessed by continuous glucose monitoring during pregnancy in women with type 1 diabetes and its association with preeclampsia, an observational Swedish cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Observational
- Role of health literacy on lifestyle and glycemic control among women with diabetes during pregnancy: a cross-sectional study.Frontiers in public health · 2024Article
- Exploring the Impact of Iron Deficiency Anaemia on Glycated Haemoglobin A1c Levels in Pregnant and Non-Pregnant Women: A Systematic Review.International journal of women's health · 2024Review
- Intrauterine Growth Restriction Due to Gestational Diabetes: From Pathophysiology to Diagnosis and Management.Medicina (Kaunas, Lithuania) · 2023Review
- Ambulatory Glucose Profile Changes During Pregnancy in Women With Type 1 Diabetes Using Intermittently Scanned Continuous Glucose Monitoring Empowered by Personalized Education.Diabetes spectrum : a publication of the American Diabetes Association · 2023Article
- Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies-Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study.Biomedicines · 2022Article
- Association Between HbA1c Levels on Adverse Pregnancy Outcomes During Pregnancy in Patients With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2022Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextDespite optimization of metabolic balance during pregnancy in type 1 diabetes (T1D), maternal-fetal complications remain higher than in the background population.
objectiveWe examined whether there is an association between glycated hemoglobin (HbA1c) levels and these complications.
methodsRetrospective study of pregnancies in 678 T1D subjects at Lille Hospital (1997-2019). The association between variations in HbA1c levels and complications was examined. The composite criterion (CC) was defined as having at least 1 of the following complications: prematurity, pre-eclampsia, large for gestational age (LGA), small for gestational age (SGA), or cesarean section.
resultsAmong the 678 births, median preconception HbA1c was 7.2% (55 mmol/mol), 361 were LGA (56%), 29 were SGA (4.5%), and 504 were births without preterm delivery (76.1%). The CC occurred in 81.8%. Higher HbA1c during the first trimester was associated with the CC (OR 1.04; 95% CI 1.02-1.06 per 0.1% increase; P < .001). Higher HbA1c during the third trimester was associated with the CC (OR 1.07; 95% CI 1.03-1.10 per 0.1% increase; P < .001). The group defined by a first trimester Hba1c >6.5% (48 mmol/mol) and a third trimester HbA1c <6% was associated with an increased rate of the CC (OR 2.81; 95% CI 1.01-7.86) and an increased rate of LGA (OR 2.20; 95% CI 1.01- 4.78).
conclusionElevated HbA1c is associated with maternal-fetal complications. Despite optimization of metabolic balance during the third trimester, for patients with early glycemic imbalance the risk of LGA persists.
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