Evidence map›Paper›PMID 34694228›Full record

ArticleJMIR research protocols2021

Four Decades of Military Posttraumatic Stress: Protocol for a Meta-analysis and Systematic Review of Treatment Approaches and Efficacy.

Jenny J W Liu, Anthony Nazarov, Bethany Easterbrook, Rachel A Plouffe, Tri Le, Callista Forchuk, Alec Brandwood, Kate St Cyr, Edouard Auger, Ken Balderson and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JMIR research protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jenny J W LiuThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0003-2213-1346
Anthony NazarovThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0002-3288-7609
Bethany EasterbrookThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0001-8741-9864
Rachel A PlouffeThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0003-0393-9008
Tri LeThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0001-6059-3870
Callista ForchukThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0001-9085-0620
Alec BrandwoodThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0003-1595-5734
Kate St CyrThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0002-5858-7612
Edouard AugerClinique pour traumatismes liés au stress opérationnel, Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale, Quebec, QC, Canada.ORCID https://orcid.org/0000-0002-2302-6225
Ken BaldersonDepartment of Psychiatry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0003-2221-1610
Mathieu BilodeauClinique pour traumatismes liés au stress opérationnel, Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale, Quebec, QC, Canada.ORCID https://orcid.org/0000-0002-4850-0560
Amer M BurhanOntario Shores Centre of Mental Health Sciences, Whitby, ON, Canada.ORCID https://orcid.org/0000-0002-9888-008X
Murray W EnnsDepartment of Psychiatry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.ORCID https://orcid.org/0000-0002-8375-0151
Patrick SmithCentre of Excellence on Post-Traumatic Stress Disorder and Related Mental Health Conditions, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0003-1746-9932
Fardous HosseinyCentre of Excellence on Post-Traumatic Stress Disorder and Related Mental Health Conditions, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-4448-2457
Gabrielle DupuisCentre of Excellence on Post-Traumatic Stress Disorder and Related Mental Health Conditions, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-5413-4536
Maya RothSt. Joseph's Operational Stress Injury Clinic, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-3668-6361
Natalie MotaDepartment of Clinical Health Psychology, University of Manitoba, Winnipeg, ON, Canada.ORCID https://orcid.org/0000-0003-2832-2223
Vicky LavoieClinique pour traumatismes liés au stress opérationnel, Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale, Quebec, QC, Canada.ORCID https://orcid.org/0000-0002-7041-6912
J Don RichardsonThe MacDonald Franklin Operational Stress Injury Research Centre, Lawson Health Research Institute, London, ON, Canada.ORCID https://orcid.org/0000-0002-2927-6735

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver 85% of active members of the Canadian Armed Forces have been exposed to potentially traumatic events linked to the development of posttraumatic stress disorder (PTSD). At the time of transition to civilian life, as high as 1 in 8 veterans may be diagnosed with PTSD. Given the high prevalence of PTSD in military and veteran populations, the provision of effective treatment considering their unique challenges and experiences is critical for mental health support and the well-being of these populations.

objectiveThis paper presents the protocol for a meta-analysis and systematic review that will examine the effectiveness of treatment approaches for military-related PTSD.

methodsThis PROSPERO-preregistered meta-analysis is being conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and Cochrane guidelines. A comprehensive search of the literature was conducted using the databases PsycInfo, Medline, Embase, CINAHL, and ProQuest Dissertation & Theses. Effect sizes will be computed based on changes in PTSD symptom scores over time across studies using validated PTSD scales. A multilevel meta-analysis will examine the overall effects, between-study effects, and within-study effects of available evidence for PTSD treatments in military populations. Effect sizes will be compared between pharmacotherapeutic, psychotherapeutic, and alternative/emerging treatment interventions. Finally, meta-regression and subgroup analyses will explore the moderating roles of clinical characteristics (eg, PTSD symptom clusters), treatment approaches (eg, therapeutic orientations in psychotherapy and alternative therapies and classifications of drugs in pharmacotherapy), as well as treatment characteristics (eg, length of intervention) on treatment outcomes.

resultsThe literature search was completed on April 14, 2021. After the removal of duplicates, a total of 12,002 studies were screened for inclusion. As of July 2021, title and abstract screening has been completed, with 1469 out of 12,002 (12.23%) studies included for full-text review. Full review is expected to be completed in the summer of 2021, with initial results expected for publication by early winter of 2021.

conclusionsThis meta-analysis will provide information on the current state of evidence on the efficacy and effectiveness of various treatment approaches for military-related PTSD and identify factors that may influence treatment outcomes. The results will inform clinical decision-making for service providers and service users. Finally, the findings will provide insights into future treatment development and practice recommendations to better support the well-being of military and veteran populations.

trial registrationPROSPERO CRD42021245754; https://tinyurl.com/y9u57c59. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/33151.

Indexed as

Canadadisorderefficacymeta-analysismilitarymilitary personnelpharmacotherapyposttraumaticposttraumatic stress disorderpsychotherapyreviewstressstress disorderssystematic reviewtherapytreatmentveteran

Identifiers

PMID34694228
PMCPMC8576591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.