Evidence map›Paper›PMID 34694178›Full record

ArticleJournal of psychopharmacology (Oxford, England)2021

Neuropsychological performance in young adults with cannabis use disorder.

Ayla Kaya, Christelle Langley, Rebecca Crean, George Savulich, Francesca Cormack, Barbara J Sahakian, Barbara Mason

Open access · hybridAbstract read
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

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  8. Ratings of executive function as a risk factor for adolescents' frequent cannabis use: A prospective longitudinal study.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023
    Article
  9. Article
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  11. Marijuana use in children: An update focusing on pediatric tetrahydrocannabinol and cannabidiol use.Journal of the American College of Emergency Physicians open · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ayla KayaDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Christelle LangleyDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5061-2820
Rebecca CreanThe Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
George SavulichDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Francesca CormackCambridge Cognition, Cambridge, UK.ORCID 0000-0002-4413-177X
Barbara J SahakianDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Barbara MasonThe Pearson Center for Alcoholism and Addiction Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
University of Cambridge · GBScripps Research Institute · USCambridge Cognition (United Kingdom) · GB

Funding

Gabapentin Treatment of Cannabis DependenceR01DA026758 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI MASON, BARBARA J · 2009 to 2013
$3.3M
NIDA NIH HHS R01 DA026758Wellcome Trust
6 · The paper itself

Abstract

BACKGROUND AND

aimsCannabis is a commonly used recreational drug in young adults. The worldwide prevalence in 18- to 25-year-olds is approximately 35%. Significant differences in cognitive performance have been reported previously for groups of cannabis users. However, the groups are often heterogeneous in terms of cannabis use. Here, we study daily cannabis users with a confirmed diagnosis of cannabis use disorder (CUD) to examine cognitive performance on measures of memory, executive function and risky decision-making.

methodsForty young adult daily cannabis users with diagnosed CUD and 20 healthy controls matched for sex and premorbid intelligence quotient (IQ) were included. The neuropsychological battery implemented was designed to measure multiple modes of memory (visual, episodic and working memory), risky decision-making and other domains of executive function using subtests from the Cambridge Neuropsychological Test Automated Battery (CANTAB).

resultsOur results showed that young adult daily cannabis users with CUD perform significantly poorer on tasks of visual and episodic memory compared with healthy controls. In addition, executive functioning was associated with the age of onset.

conclusionsFurther research is required to determine whether worse performance in cognition results in cannabis use or is a consequence of cannabis use. Chronic heavy cannabis use during a critical period of brain development may have a particularly negative impact on cognition. Research into the persistence of cognitive differences and how they relate to functional outcomes such as academic/career performance is required.

Indexed as

AdultCaliforniaCognitive DysfunctionFemaleHumansMaleMarijuana AbuseNeuropsychological TestsPsychomotor PerformanceYoung Adultcannabis use disorderCANTABCognition

Identifiers

PMID34694178
PMCPMC8600580
OpenAlexW3210800812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.