Evidence map›Paper›PMID 34694145›Full record

ArticleCirculation2021

Kunzhe Dong, Jian Shen, Xiangqin He, Guoqing Hu, Liang Wang, Islam Osman, Kristopher M Bunting, Rachael Dixon-Melvin, Zeqi Zheng, Hongbo Xin and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
  2. Review
  3. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  4. Article
  5. The dark genome in cardiovascular medicine.European heart journal · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Coronary artery disease risk gene PRDM16 regulates smooth muscle homeostasis.Journal of molecular and cellular cardiology · 2026
    Article
  10. Enhancer Dynamics for Gene Regulation in the Cardiovascular System.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  11. Review
  12. Review
  13. Article
  14. Role of eRNAs in Cardiovascular Diseases.Current cardiology reviews · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Kunzhe Dong *Department of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.ORCID 0000-0003-0039-9835
Jian Shen *Department of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.
Xiangqin HeDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.
Guoqing HuDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.
Liang WangDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.
Islam OsmanDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.ORCID 0000-0002-9494-8219
Kristopher M BuntingDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.ORCID 0000-0002-7252-8598
Rachael Dixon-MelvinDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.ORCID 0000-0003-1320-4646
Zeqi ZhengDepartment of Cardiology, The First Affiliated Hospital of Nanchang University, Jiangxi, China (L.W., Z.Z.).
Hongbo XinSchool of Life Sciences (H.X.), Nanchang University, Jiangxi, China.ORCID 0000-0002-4257-207X
Meixiang XiangDepartment of Cardiology, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China (J.S., M.X.).ORCID 0000-0003-0255-6056
Almira VazdarjanovaDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.
David J R FultonDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.
Jiliang ZhouDepartment of Pharmacology and Toxicology (K.D., J.S., X.H., G.H., L.W., I.O., K.M.B., R.D.-M., A.V., D.J.R.F., J.Z.), Medical College of Georgia, Augusta University.ORCID 0000-0002-2375-4636
Augusta University · USNanchang University · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

Circadian origins of vascular disease in obesityR01HL147159 · NHLBI · AUGUSTA UNIVERSITY · PI FULTON, DAVID J, STEPP, DAVID W · 2019 to 2022
$2.7M
The novel smooth muscle-specific lncRNA CARMN is a critical regulator of smooth muscle phenotypeR01HL149995 · NHLBI · AUGUSTA UNIVERSITY · PI ZHOU, JILIANG · 2020 to 2023
$2.0M
YAP1, neointima formation, and blood pressure regulationK99HL153896 · NHLBI · AUGUSTA UNIVERSITY · PI OSMAN, ISLAM · 2020 to 2021
$246k
American Heart Association-American Stroke Association 17EIA33460468American Heart Association-American Stroke Association 19TPA34910181NHLBI NIH HHS K99 HL153896NHLBI NIH HHS R01 HL147159NHLBI NIH HHS R01 HL149995
6 · The paper itself

Abstract

backgroundVascular homeostasis is maintained by the differentiated phenotype of vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising the transcriptome of differentiated VSMCs has been intensively investigated but many gaps remain including the emerging roles of noncoding genes.

methodsWe reanalyzed large-scale, publicly available bulk and single-cell RNA sequencing datasets from multiple tissues and cell types to identify VSMC-enriched long noncoding RNAs. The in vivo expression pattern of a novel smooth muscle cell (SMC)-expressed long noncoding RNA,

resultsWe identified

conclusions

Indexed as

Muscle ContractionAnimalsHumansMiceMuscle, SmoothMuscle, Smooth, VascularMyocardinNuclear ProteinsRatsRNA, Long NoncodingTrans-ActivatorsMyocardinNuclear ProteinsRNA, Long NoncodingTrans-Activatorsmyocytes, smooth muscleRNA, long noncodingvascular diseases

Identifiers

PMID34694145
PMCPMC8726016
OpenAlexW3208366362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.