ReviewJournal of paediatrics and child health2022
COVID-19 in children. II: Pathogenesis, disease spectrum and management.
Review in Journal of paediatrics and child health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pediatric COVID-19 in Argentina: a comprehensive analysis of disease and economic burden through official data and a systematic literature review.Frontiers in pediatrics · 2024Pooled it
- Pooled it
- Mental health and quality of life in children and adolescents during the COVID-19 pandemic: a systematic review of longitudinal studies.Frontiers in public health · 2023Pooled it
- The effect of smaller classes on infection-related school absence: evidence from the Project STAR randomized controlled trial.BMC public health · 2024Trial
- Immunogenicity of COVID-19 booster vaccines in children receiving immunosuppressive medications.Pediatric research · 2026Observational
- Article
- Referral patterns surrounding the COVID-19 pandemic to a child and adolescent mental health clinic in Gauteng, South Africa.Frontiers in psychiatry · 2026Article
- A perfect storm: the immunological and pathophysiological landscape of pediatric post-COVID-19 condition.Frontiers in immunology · 2026Review
- Vaccine Hesitancy and Refusal Among Parents of Children Aged 5-11 Years: Evidence from the COVID-19 Pandemic in the Calabria Region.Vaccines · 2025Article
- Psychological distress and COVID-19 vaccine hesitancy among parents of in-school children after the end of the zero-COVID-19 policy: A city-wide survey in South China.Human vaccines & immunotherapeutics · 2025Article
- Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data.The Journal of clinical endocrinology and metabolism · 2025Article
- Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia.PLoS medicine · 2025Article
- Duration of COVID-19 symptoms in children: a longitudinal study in a Rio de Janeiro favela, Brazil.BMJ open · 2025Article
- EFFECT OF PAXLOVID TREATMENT DURING ACUTE COVID-19 ON LONG COVID ONSET: AN EHR-BASED TARGET TRIAL EMULATION FROM THE N3C AND RECOVER CONSORTIA.medRxiv : the preprint server for health sciences · 2025Article
- PaedVacCOVID - safety of the BNT162b2 vaccine against the SARS-CoV-2 in children with and without comorbidities aged 5 to 11 years.Infection · 2025Article
- Post COVID-19 conditions in an Australian pediatric cohort, 3 months following a Delta outbreak.Pediatric research · 2025Article
- Observational
- Analysis of epidemic trend of respiratory pathogens in children after long-term pathogen isolation.PeerJ · 2025Article
- Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C.PLoS medicine · 2025Article
- Incidence and severity of SARS-CoV-2 infection and vaccine BNT162 side effects in children and adolescents with Noonan Syndrome: a national multicentric study.Frontiers in pediatrics · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global disruption of the COVID-19 pandemic has impacted the life of every child either directly or indirectly. This review explores the pathophysiology, immune response, clinical presentation and treatment of COVID-19 in children, summarising the most up-to-date data including recent developments regarding variants of concern. The acute infection with SARS-CoV-2 is generally mild in children, whilst the post-infectious manifestations, including paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) and 'long COVID' in children, are more complex. Given that most research on COVID-19 has focused on adult cohorts and that clinical manifestations, treatment availability and impacts differ markedly in children, research that specifically examines COVID-19 in children needs to be prioritised.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.