ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2022
3D Harmonic and Subharmonic Imaging for Characterizing Breast Lesions: A Multi-Center Clinical Trial.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Comparison of ultrasound contrast agent production by sonication and mechanical agitation.Ultrasonics sonochemistry · 2026Article
- Real-time deep learning for tumor segmentation and tool tracking: development and validation of an AI navigation system in vacuum-assisted breast biopsy.World journal of surgical oncology · 2025Article
- Effects of Different Gas Cores on the Ambient Pressure Sensitivity of the Subharmonic Response of SonoVue.Ultrasound in medicine & biology · 2025Article
- Acoustic response and ambient pressure sensitivity characterization of SonoVue for noninvasive pressure estimation.The Journal of the Acoustical Society of America · 2024Article
- Quantitative US Delta Radiomics to Predict Radiation Response in Individuals with Head and Neck Squamous Cell Carcinoma.Radiology. Imaging cancer · 2024Observational
- Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system.Ultrasonics sonochemistry · 2023Article
- Ambient Pressure Sensitivity of the Subharmonic Response of Coated Microbubbles: Effects of Acoustic Excitation Parameters.Ultrasound in medicine & biology · 2023Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveBreast cancer is the most frequent type of cancer among women. This multi-center study assessed the ability of 3D contrast-enhanced ultrasound to characterize suspicious breast lesions using clinical assessments and quantitative parameters.
methodsWomen with suspicious breast lesions scheduled for biopsy were enrolled in this prospective, study. Following 2D grayscale ultrasound and power Doppler imaging (PDI), a contrast agent (Definity; Lantheus) was administrated. Contrast-enhanced 3D harmonic imaging (HI; transmitting/receiving at 5.0/10.0 MHz), as well as 3D subharmonic imaging (SHI; transmitting/receiving at 5.8/2.9 MHz), were performed using a modified Logiq 9 scanner (GE Healthcare). Five radiologists independently scored the imaging modes (including standard-of-care imaging) using a 7-point BIRADS scale as well as lesion vascularity and diagnostic confidence. Parametric volumes were constructed from time-intensity curves for vascular heterogeneity, perfusion, and area under the curve. Diagnostic accuracy was determined relative to pathology using receiver operating characteristic (ROC) and reverse, step-wise logistical regression analyses. The κ-statistic was calculated for inter-reader agreement.
resultsData were successfully acquired in 219 cases and biopsies indicated 164 (75%) benign and 55 (25%) malignant lesions. SHI depicted more anastomoses and vascularity than HI (P < .021), but there were no differences by pathology (P > .27). Ultrasound achieved accuracies of 82 to 85%, which was significantly better than standard-of-care imaging (72%; P < .03). SHI increased diagnostic confidence by 3 to 6% (P < .05), but inter-reader agreements were medium to low (κ < 0.52). The best regression model achieved 97% accuracy by combining clinical reads and parametric SHI.
conclusionsCombining quantitative 3D SHI parameters and clinical assessments improves the characterization of suspicious breast lesions.
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