ArticleeLife2021
Subpopulations of neurons in lOFC encode previous and current rewards at time of choice.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
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- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
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- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Alpha Modulation of Spiking Activity Across Multiple Brain Regions in Mice Performing a Tactile Selective Detection Task.The European journal of neuroscience · 2025Article
- Pre-existing and emergent cortical neuronal assembly sequences during learning.bioRxiv : the preprint server for biology · 2025Article
- The orbitofrontal cortex updates beliefs for state inference.bioRxiv : the preprint server for biology · 2025Article
- Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control.Nature communications · 2025Article
- Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy.bioRxiv : the preprint server for biology · 2025Article
- The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space.Communications biology · 2025Article
- Single-unit activity in the anterior claustrum during memory retrieval after trace fear conditioning.PloS one · 2025Article
- Modular representations emerge in neural networks trained to perform context-dependent tasks.bioRxiv : the preprint server for biology · 2024Article
- Review
- Computational role of structure in neural activity and connectivity.Trends in cognitive sciences · 2024Review
- Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making.iScience · 2024Article
- The rat frontal orienting field dynamically encodes value for economic decisions under risk.Nature neuroscience · 2023Article
- Semi-orthogonal subspaces for value mediate a tradeoff between binding and generalization.ArXiv · 2023Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Studies of neural dynamics in lateral orbitofrontal cortex (lOFC) have shown that subsets of neurons that encode distinct aspects of behavior, such as value, may project to common downstream targets. However, it is unclear whether reward history, which may subserve lOFC's well-documented role in learning, is represented by functional subpopulations in lOFC. Previously, we analyzed neural recordings from rats performing a value-based decision-making task, and we documented trial-by-trial learning that required lOFC (Constantinople et al., 2019). Here, we characterize functional subpopulations of lOFC neurons during behavior, including their encoding of task variables. We found five distinct clusters of lOFC neurons, either based on clustering of their trial-averaged peristimulus time histograms (PSTHs), or a feature space defined by their average conditional firing rates aligned to different task variables. We observed weak encoding of reward attributes, but stronger encoding of reward history, the animal's left or right choice, and reward receipt across all clusters. Only one cluster, however, encoded the animal's reward history at the time shortly preceding the choice, suggesting a possible role in integrating previous and current trial outcomes at the time of choice. This cluster also exhibits qualitatively similar responses to identified corticostriatal projection neurons in a recent study (Hirokawa et al., 2019), and suggests a possible role for subpopulations of lOFC neurons in mediating trial-by-trial learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.