Evidence map›Paper›PMID 34693870›Full record

ArticlePharmaceutical biology2021

Ahmad Khusairi Azemi, Siti Safiah Mokhtar, Sharifah Emilia Tuan Sharif, Aida Hanum Ghulam Rasool

Open access · goldFull text readComparative Study
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Antiviral and Immunomodulatory Activities ofInternational journal of molecular sciences · 2023
    Review
  9. Clinical medicine insights. Endocrinology and diabetes · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ahmad Khusairi AzemiDepartment of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0002-1632-9754
Siti Safiah MokhtarDepartment of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0002-0114-5573
Sharifah Emilia Tuan SharifDepartment of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0002-0343-4205
Aida Hanum Ghulam RasoolDepartment of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0001-5418-953X
Hospital Universiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextAtherosclerosis predisposes individuals to adverse cardiovascular events.

objectivesTo investigate the anti-atherosclerotic activity of a MATERIALS AND

methodsSixty male Sprague-Dawley rats were divided into five groups: non-diabetic fed a standard diet (C), C + CNME (500 mg/kg, orally), diabetic fed an HFD (DM), DM + CNME (500 mg/kg), and DM + Metformin (DM + Met; 300 mg/kg). Treatment with oral CNME and metformin was administered for 4 weeks. Fasting blood glucose (FBG), serum lipid profile, atherogenic index (AI), aortic tissue superoxide dismutase levels (SOD), malondialdehyde (MDA), and tumour necrosis factor-alpha (TNF-α) were measured. The rats' aortas were stained for histological analysis and intima-media thickness (IMT), a marker of subclinical atherosclerosis.

resultsThe CNME-treated diabetic rats had reduced serum total cholesterol (43.74%;

conclusions

Indexed as

AcanthaceaeAnimalsAtherosclerosisDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diet, High-FatDisease ProgressionInflammationMaleMetforminOxidative StressPlant ExtractsRatsRats, Sprague-DawleyStreptozocinMetforminPlant ExtractsStreptozocinanti-atherosclerosisatherogenic indexintima-media thicknessMDASODTNF-α

Identifiers

PMID34693870
PMCPMC8553363
OpenAlexW3211143686

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.