Evidence map›Paper›PMID 34693742›Full record

ArticleAmerican journal of physiology. Renal physiology2021

A new view of macula densa cell protein synthesis.

Urvi Nikhil Shroff, Georgina Gyarmati, Audrey Izuhara, Sachin Deepak, János Peti-Peterdi

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Urvi Nikhil ShroffDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California.
Georgina GyarmatiDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California.
Audrey IzuharaDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California.
Sachin DeepakDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California.
János Peti-PeterdiDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California.ORCID 0000-0003-4092-6185
University of Southern California · US

Funding

Multiphoton Imaging of the Juxtaglomerular ApparatusR01DK064324 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2004 to 2026
$8.4M
Novel regulatory mechanisms of the glomerular endotheliumR01DK123564 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2019 to 2026
$3.5M
Multiphoton microscope replacement for USC shared resourceS10OD021833 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PETI-PETERDI, JANOS · 2017 to 2017
$600k
NIDDK NIH HHS R01 DK064324NIDDK NIH HHS R01 DK123564NIH HHS S10 OD021833
6 · The paper itself

Abstract

Macula densa (MD) cells, a chief sensory cell type in the nephron, are endowed with unique microanatomic features including a high density of protein synthetic organelles and secretory vesicles in basal cell processes ("maculapodia") that suggest a so far unknown high rate of MD protein synthesis. This study aimed to explore the rate and regulation of MD protein synthesis and their effects on glomerular function using novel transgenic mouse models, newly established fluorescence cell biology techniques, and intravital microscopy. Sox2-tdTomato kidney tissue sections and an

Indexed as

Protein BiosynthesisAnimalsAutocrine CommunicationDiet, Sodium-RestrictedGlomerular Filtration RateGreen Fluorescent ProteinsHumansIntravital MicroscopyJuxtaglomerular ApparatusLuminescent ProteinsMiceMice, Inbred C57BLMice, TransgenicMicroscopy, Fluorescence, MultiphotonNitric Oxide Synthase Type IParacrine Communicationenhanced green fluorescent proteinGreen Fluorescent ProteinsLuminescent ProteinsmTOR protein, mouseNitric Oxide Synthase Type INos1 protein, mouseRed Fluorescent ProteinReninSodium, DietaryTOR Serine-Threonine KinasesTsc2 protein, mouseTuberous Sclerosis Complex 2 Proteinglomerular filtration ratemacula densamTORprotein synthesisrenin

Identifiers

PMID34693742
PMCPMC8714974
OpenAlexW3209405236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.