Evidence map›Paper›PMID 34693473›Full record

SynthesisEsophagus : official journal of the Japan Esophageal Society2022

The potential for reducing alcohol consumption to prevent esophageal cancer morbidity in Asian heavy drinkers: a systematic review and meta-analysis.

Yuto Kubo, Yuko Kitagawa, Tatsuya Miyazaki, Makoto Sohda, Taiki Yamaji, Makoto Sakai, Hiroshi Saeki, Kenji Nemoto, Tsuneo Oyama, Manabu Muto and 23 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Esophagus : official journal of the Japan Esophageal Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Subtype-specific associations of steatotic liver disease with gastric and esophageal cancers: a nationwide cohort study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 1 country.

Yuto KuboDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 E2 Yamadaoka, Suita, Osaka, 565-0871, Japan. ykubo@gesurg.med.osaka-u.ac.jp.ORCID 0000-0002-4017-1272
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Tatsuya MiyazakiDepartment of Surgery, Japanese Red Cross Maebashi Hospital, Maebashi, Gunma, Japan.
Makoto SohdaDivision of Gastroenterological Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Taiki YamajiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Makoto SakaiDivision of Gastroenterological Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Hiroshi SaekiDivision of Gastroenterological Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Kenji NemotoDepartment of Radiology, Yamagata University Graduate School of Medicine, Yamagata, Japan.
Tsuneo OyamaDepartment of Endoscopy, Saku Central Hospital Advanced Care Center, Nagano, Japan.
Manabu MutoDepartment of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hiroya TakeuchiDepartment of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Yasushi TohDepartment of Gastroenterological Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Hisahiro MatsubaraDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masayuki ManoDepartment of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Koji KonoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima, Japan.
Ken KatoDepartment of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Masahiro YoshidaDepartment of Hemodialysis and Surgery, Chemotherapy Research Institute, International University of Health and Welfare, Ichikawa, Japan.
Hirofumi KawakuboDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Eisuke BookaDepartment of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Tomoki YamatsujiDepartment of General Surgery, Kawasaki Medical School, Okayama, Japan.
Hiroyuki KatoKiryu Kousei General Hospital, Gunma, Japan.
Yoshinori ItoDepartment of Radiation Oncology, Showa University School of Medicine, Tokyo, Japan.
Hitoshi IshikawaNational Institutes for Quantum and Radiological Science and Technology, QST Hospital, Chiba, Japan.
Ryu IshiharaDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Takahiro TsushimaDivision of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Hiroshi KawachiDepartment of Pathology, The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Tokyo, Japan.
Takashi OyamaDepartment of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, International University of Health and Welfare School of Medicine, Chiba, Japan.
Takashi KojimaDepartment of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.
Shiko KuribayashiDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Gunma, Japan.
Tomoki MakinoDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 E2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Satoru MatsudaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Yuichiro DokiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 E2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Esophageal Cancer Practice Guidelines Preparation Committee
Gunma University · JPKeio University · JPThe University of Osaka · JPHamamatsu University School of Medicine · JPNational Cancer Center Hospital East · JPSaku Central Hospital · JPChiba University · JPFukushima Medical University · JPInternational University of Health and Welfare · JPJapanese Foundation For Cancer Research · JPKawasaki Medical School · JPKiryu University · JPKyoto University · JPMaebashi Red Cross Hospital · JPNational Center for Global Health and Medicine · JPNational Hospital Organization Kyushu Cancer Center · JPNational Institutes for Quantum Science and Technology · JPOsaka International Cancer Institute · JPShizuoka Cancer Center · JPShowa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol consumption is a major risk factor for esophageal cancer. In Asia, heavy drinkers are considered to have a higher risk of esophageal cancer than nondrinkers and light drinkers. However, no study has shown an association between alcohol reduction and the morbidity of esophageal cancer in Asian heavy drinkers. Therefore, this study investigated the significance of reducing alcohol consumption to prevent esophageal cancer in Asian heavy drinkers by conducting a systematic review and meta-analysis. The MEDLINE (PubMed) and ICHUSHI (Japana Centra Revuo Medicina) databases were searched from January 1995 to December 2020. The hazard ratio (HR) and 95% confidence interval (CI) were calculated using a random-effects model. I

Indexed as

Alcohol DrinkingEsophageal NeoplasmsHumansIncidenceProportional Hazards ModelsRisk FactorsAbstinenceAlcohol consumptionEsophageal cancerHeavy drinkersSobriety

Identifiers

PMID34693473
OpenAlexW3211301207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.