Evidence map›Paper›PMID 34693388›Full record

ArticleThe Lancet regional health. Europe2021

The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey.

Simon Mark Dahl Baunwall, Elisabeth M Terveer, Jens Frederik Dahlerup, Christian Erikstrup, Perttu Arkkila, Maria Jgt Vehreschild, Gianluca Ianiro, Antonio Gasbarrini, Harry Sokol, Patrizia K Kump and 30 more

Abstract read
In one paragraph

Article in The Lancet regional health. Europe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Trial
  2. Cost-Effectiveness of Hospital-at-Home and Fecal Microbiota Transplantation in Treating Older Patients With Clostridioides difficile.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  3. Transient colonization with Blastocystis spp. after transmission via fecal microbiota transplantation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Trial
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  15. TacklingThe Lancet regional health. Europe · 2025
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  16. Comparative effectiveness of different therapies forThe Lancet regional health. Europe · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Simon Mark Dahl BaunwallDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus, Denmark.
Elisabeth M TerveerDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Jens Frederik DahlerupDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus, Denmark.
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Perttu ArkkilaDepartment of Gastroenterology, Helsinki University Hospital and Helsinki University, Helsinki, Finland.
Maria Jgt VehreschildDepartment of Internal Medicine II, Infectious Diseases, University Hospital Frankfurt, Frankfurt am Main, Germany.
Gianluca IaniroDigestive Disease Center, CEMAD, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Antonio GasbarriniDigestive Disease Center, CEMAD, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Harry SokolSorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Paris, France.
Patrizia K KumpDivision of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria.
Reetta SatokariHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Danny De LoozeDepartment of Gastroenterology, Ghent University Hospital, Ghent, Belgium.
Séverine VermeireDepartment Gastroenterology and Hepatology, KU Leuven University Hospitals Leuven & KU Leuven, Belgium.
Radislav NakovClinic of Gastroenterology, Tsaritsa Yoanna University Hospital, Sofia, Bulgaria.
Jan BrezinaHepatogastroenterology Department, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Morten HelmsDepartment of Infectious Diseases, Copenhagen University Hospital Hvidovre, Denmark.
Jens KjeldsenDepartment of Medical Gastroenterology, Odense University Hospital Research Unit of Medical Gastroenterology, Odense, Denmark.
Anne A RodeDepartment of Medicine, Zealand University Hospital, Køge, Denmark.
Sabrina Just KousgaardDepartment of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark.
Laurent AlricDepartment of Internal Medicine and Digestive Diseases, IRD Toulouse 3 University, Toulouse, France.
Caroline Trang-PoissonGastroenterology Department, Institut des maladies de l'Appareil Digestif (IMAD), Centre d'investigation Clinique IMAD, University Hospital, Hotel-Dieu, Nantes, France.
Julien ScanziFrench Group of Faecal Microbiota Transplantation (GFTF), Paris, France.
Alexander LinkDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany.
Andreas StallmachDepartment of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Jena, Germany.
Juozas KupcinskasDepartment of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Peter Holger JohnsenUniversity Hospital of North Norway Harstad, Harstad, Norway.
Kjetil GarborgDepartment of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.
Eugenia Sánchez RodríguezServicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Lena SerranderDivision of Clinical Microbiology, Linköping University Hospital, Linköping, Sweden.
Robert J BrummerNutrition-Gut-Brain Interactions Research Centre, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden.
Katerina Tatiana GalpérineFrench Group of Faecal Microbiota Transplantation (GFTF), Paris, France.
Simon D GoldenbergCentre for Clinical Infection and Diagnostics Research (CIDR), King's College London and Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Benjamin H MullishDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.
Horace Rt WilliamsDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.
Tariq H IqbalDepartment of Gastroenterology, Institute of Immunology and Immunotherapy, University of Birmingham, University Hospital, Birmingham, United Kingdom.
Cyriel PonsioenDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Ed J KuijperNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, the Netherlands.
Giovanni CammarotaDigestive Disease Center, CEMAD, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Josbert J KellerNetherlands Donor Feces Bank, Leiden University Medical Center, Leiden, the Netherlands.
Christian Lodberg HvasDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFaecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the clinical use, conduct, and potential for FMT in Europe.

methodsWe invited all hospital-based FMT centres within the European Council member states to answer a web-based questionnaire covering their clinical activities, organisation, and regulation of FMT in 2019. Responders were identified from trials registered at clinicaltrials.gov and from the United European Gastroenterology (UEG) working group for stool banking and FMT.

findingsIn 2019, 31 FMT centres from 17 countries reported a total of 1,874 (median 25, quartile 10-64) FMT procedures; 1,077 (57%) with

interpretationFMT is a widespread routine treatment for multiple, recurrent CDI and an experimental treatment. Embedded within hospital settings, FMT centres operate with high standards across Europe to provide safe FMT. A significant gap in FMT coverage suggests the need to raise clinical awareness and increase the FMT activity in Europe by at least 10-fold to meet the true, indicated need.

fundingNordForsk under the Nordic Council and Innovation Fund Denmark (j.no. 8056-00006B).

Indexed as

Abbreviations: CDI, Clostridioides difficile infectionClostridioides difficileECDC, European Centre for Disease Prevention and ControlFaecal microbiota transplantationFMTFMT, Faecal microbiota transplantationIQR, Interquartile rangeREDCap, Research Data Capture softwareSARS-CoV-2, Severe acute respiratory syndrome coronavirus 2Stool bankingUEG, United Gastroenterology European

Identifiers

PMID34693388
PMCPMC8513118

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.