Evidence map›Paper›PMID 34693376›Full record

ArticlePatterns (New York, N.Y.)2021

Knowledge transfer to enhance the performance of deep learning models for automated classification of B cell neoplasms.

Nanditha Mallesh, Max Zhao, Lisa Meintker, Alexander Höllein, Franz Elsner, Hannes Lüling, Torsten Haferlach, Wolfgang Kern, Jörg Westermann, Peter Brossart and 2 more

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
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  7. Article
  8. MLP-PSO Hybrid Algorithm for Heart Disease Prediction.Journal of personalized medicine · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nanditha MalleshInstitute for Genomic Statistics and Bioinformatics, University Bonn, Bonn, Germany.
Max ZhaoInstitute for Genomic Statistics and Bioinformatics, University Bonn, Bonn, Germany.
Lisa MeintkerDepartment of Medicine 5, Universitätsklinikum Erlangen, Erlangen, Germany.
Alexander HölleinMLL Munich Leukemia Laboratory, Munich, Germany.
Franz Elsnerres mechanica GmbH, Munich, Germany.
Hannes Lülingres mechanica GmbH, Munich, Germany.
Torsten HaferlachMLL Munich Leukemia Laboratory, Munich, Germany.
Wolfgang KernMLL Munich Leukemia Laboratory, Munich, Germany.
Jörg WestermannDepartment of Hematology, Oncology and Tumor Immunology, Charité-Campus Virchow Clinic and Labor Berlin Charité Vivantes, Berlin, Germany.
Peter BrossartDepartment of Oncology, Hematology, Immuno-oncology and Rheumatology, University Hospital of Bonn, Bonn, Germany.
Stefan W KrauseDepartment of Medicine 5, Universitätsklinikum Erlangen, Erlangen, Germany.
Peter M KrawitzInstitute for Genomic Statistics and Bioinformatics, University Bonn, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi-parameter flow cytometry (MFC) is a cornerstone in clinical decision making for leukemia and lymphoma. MFC data analysis requires manual gating of cell populations, which is time-consuming, subjective, and often limited to a two-dimensional space. In recent years, deep learning models have been successfully used to analyze data in high-dimensional space and are highly accurate. However, AI models used for disease classification with MFC data are limited to the panel they were trained on. Thus, a key challenge in deploying AI into routine diagnostics is the robustness and adaptability of such models. This study demonstrates how transfer learning can be applied to boost the performance of models with smaller datasets acquired with different MFC panels. We trained models for four additional datasets by transferring the features learned from our base model. Our workflow increased the model's overall performance and, more prominently, improved the learning rate for small training sizes.

Indexed as

classificationdecision-supportdeep learningFCS data mergeflow cytometrylymphomaneoplasmopen sourcetransfer learning

Identifiers

PMID34693376
PMCPMC8515009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.