Evidence map›Paper›PMID 34693295›Full record

ArticleInternational journal of neurodegenerative disorders2021

Fragmentation of Apolipoprotein E4 is Required for Differential Expression of Inflammation and Activation Related Genes in Microglia Cells.

Troy T Rohn, James D Beck, Stephanie J Galla, Noail F Isho, Tanner B Pollock, Tarun Suresh, Arni Kulkarni, Tanya Sanghal, Eric J Hayden

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of neurodegenerative disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Troy T RohnDepartment of Biological Sciences, Boise State University, USA.
James D BeckDepartment of Biological Sciences, Boise State University, USA.
Stephanie J GallaDepartment of Biological Sciences, Boise State University, USA.
Noail F IshoUniversity of Washington School of Medicine, University of Washington, USA.
Tanner B PollockDepartment of Biological Sciences, Boise State University, USA.
Tarun SureshDepartment of Biological Sciences, Boise State University, USA.
Arni KulkarniDepartment of Biological Sciences, Boise State University, USA.
Tanya SanghalDepartment of Biological Sciences, Boise State University, USA.
Eric J HaydenDepartment of Biological Sciences, Boise State University, USA.
Boise State University · USUniversity of Washington · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2014 to 2023
$22.7M
Nuclear Localization of an Amino-Terminal Fragment of Apolipoprotein E4 in the Alzheimer's Disease BrainR15AG042781 · NIA · BOISE STATE UNIVERSITY · PI ROHN, TROY T · 2013 to 2022
$1.1M
NIA NIH HHS R15 AG042781NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095
6 · The paper itself

Abstract

The apolipoprotein E4 (

Indexed as

Alzheimer’s diseaseApolipoprotein E4BV2 cellsFragment of ApoE4InflammationMicroglia cellsRNA-seqToxicityTranscriptome analysis

Identifiers

PMID34693295
PMCPMC8529910
OpenAlexW3199998146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.