Evidence map›Paper›PMID 34693284›Full record

ArticleBrain communications2021

Evidence for

Mike A Nalls, Cornelis Blauwendraat, Lana Sargent, Dan Vitale, Hampton Leonard, Hirotaka Iwaki, Yeajin Song, Sara Bandres-Ciga, Kevin Menden, Faraz Faghri and 3 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Mike A NallsCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.
Cornelis BlauwendraatCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-9358-8111
Lana SargentCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-5555-9985
Dan VitaleCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-0637-3671
Hampton LeonardCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.
Hirotaka IwakiCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.
Yeajin SongCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.
Sara Bandres-CigaCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.
Kevin MendenGerman Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.ORCID https://orcid.org/0000-0002-5228-985X
Faraz FaghriCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-5744-8728
Peter HeutinkGerman Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.
Mark R CooksonCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.
Andrew B SingletonCenter for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD 20892, USA.
National Institutes of Health · USGerman Center for Neurodegenerative Diseases · DE

Funding

Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
Intramural NIH HHS Z01 AG000949
6 · The paper itself

Abstract

Previous research using genome-wide association studies has identified variants that may contribute to lifetime risk of multiple neurodegenerative diseases. However, whether there are common mechanisms that link neurodegenerative diseases is uncertain. Here, we focus on one gene,

Indexed as

Alzheimer’samyotrophic lateral sclerosisgene expressionParkinson’starget

Identifiers

PMID34693284
PMCPMC8134835
OpenAlexW3164943245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.