Evidence map›Paper›PMID 34693252›Full record

ArticleKidney medicine

Kidney Function and Aortic Stiffness, Pulsatility, and Endothelial Function in African Americans: The Jackson Heart Study.

Harsha S Nagarajarao, Solomon K Musani, Keith E Cobb, James D Pollard, Leroy L Cooper, Anshul Anugu, Yuichiro Yano, Josiah A Moore, Connie W Tsao, Albert W Dreisbach and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Article
  6. Albuminuria: An Underappreciated Risk Factor for Cardiovascular Disease.Journal of the American Heart Association · 2024
    Review
  7. Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling.American journal of physiology. Heart and circulatory physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Harsha S NagarajaraoDepartment of Medicine, Texas Tech University of Health Sciences, El Paso, TX.
Solomon K MusaniDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Keith E CobbBiology Department, Vassar College, Poughkeepsie, NY.
James D PollardDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Leroy L CooperBiology Department, Vassar College, Poughkeepsie, NY.
Anshul AnuguUniversity of Mississippi, Oxford, MS.
Yuichiro YanoDepartment of Medicine, Duke University, Durham, NC.
Josiah A MooreWashington University, St. Louis, MO.
Connie W TsaoDepartment of Medicine, Beth Israel Medical Center.
Albert W DreisbachDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Emelia J BenjaminDepartment of Medicine, Boston University School of Medicine, Boston.
Naomi M HamburgDepartment of Medicine, Boston University School of Medicine, Boston.
Ramachandran S VasanDepartment of Medicine, Boston University School of Medicine, Boston.
Gary F MitchellCardiovascular Engineering Inc, Norwood, MA.
Ervin R FoxDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
University of Mississippi Medical Center · USBoston University · USVassar College · USDuke University · USNorwood Hospital · USTexas Tech University · USUniversity of Mississippi · USWashington University in St. Louis · US

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
ConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8M
Clinical and Genetic Correlates of Vascular Function in African Americans: JHSR01HL104184 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI FOX, ERVIN R · 2011 to 2017
$4.5M
AFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1M
Vascular Stiffness as a Precursor of Hypertension in a Middle-aged CohortR01HL126136 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2015 to 2018
$2.6M
Aortic Dysfunction, Pulsatile Stress and Target Organ Damage in FraminghamR01HL107385 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2011 to 2014
$2.6M
AORTA, BRAIN AND KIDNEY STRUCTURE AND FUNCTION IN THE AGES-REYKJAVIK STUDYR01HL094898 · NHLBI · CARDIOVASCULAR ENGINEERING, INC. · PI MITCHELL, GARY FRANK · 2009 to 2012
$2.5M
FHS-NEXT - Framingham Novel EXam using TechnologyR01HL141434 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., MCMANUS, DAVID D. · 2019 to 2022
$2.5M
Kidney Function, Aortic Stiffness and AgingR01DK082447 · NIDDK · TUFTS MEDICAL CENTER · PI LEVEY, ANDREW S · 2010 to 2014
$2.4M
Determinants and Prognostic Significance of Proximal Aortic StiffnessK23HL118529 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TSAO, CONNIE · 2014 to 2018
$742k
NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS K23 HL118529NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL094898NHLBI NIH HHS R01 HL104184NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL141434NHLBI NIH HHS U54 HL120163NIDDK NIH HHS R01 DK082447
6 · The paper itself

Abstract

RATIONALE &

objectiveThe relation of vascular stiffness, endothelial function, and kidney function is incompletely elucidated in African Americans. Our hypothesis was that increased vascular stiffness and endothelial dysfunction are associated with low estimated glomerular filtration rate (eGFR) and albuminuria in African Americans. STUDY

designCross-sectional cohort analysis of data from the Jackson Heart Study. SETTINGS & PATIENTS: 2,244 Jackson Heart Study participants (2012-2017 after Exam 3) who had undergone noninvasive hemodynamic assessment using arterial tonometry. PREDICTORS: Baseline carotid-femoral pulse wave velocity, pulsatile hemodynamics forward wave amplitude, and hyperemic brachial artery flow were measured. Reduced eGFR was defined as eGFR between 15 and 60 mL/min/1.73 m OUTCOMES: Prevalent albuminuria, urinary albumin-creatinine ratio. ANALYTICAL APPROACH: 2-sample

resultsAmong 2,244 participants, mean age was 66 ± 11 years and 64% were women. Reduced eGFR was present in 233 (10.4%), and elevated urinary albumin-creatinine ratio, in 232 (10.4%). In multivariable-adjusted analyses, higher carotid-femoral pulse wave velocity was associated with the presence of reduced eGFR (OR, 1.37 [95% CI, 1.08-1.75] per SD; LIMITATIONS: Cross-sectional analyses cannot inform causality.

conclusionsHigher arterial stiffness and pulsatility are associated with higher odds of reduced eGFR in African Americans. Future studies should focus on whether improving arterial stiffness contributes to kidney protection in African Americans.

Indexed as

African AmericansArterial stiffnessChronic kidney diseaseeGFR

Identifiers

PMID34693252
PMCPMC8515070
OpenAlexW3180347337

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.