Evidence map›Paper›PMID 34693054›Full record

ArticleHeliyon2021

Developing novel anthelmintics: the stability of cysteine proteinase activity in a supernatant extract of papaya latex.

F A F Mansur, W Luoga, J M Behnke, D J Buttle, I R Duce, M C Garnett

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Infection and immunity · 2023
    Article
  2. Review
  3. Improvement of cell suspension cultures of transformed and untransformedFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

F A F MansurSchool of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
W LuogaSchool of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
J M BehnkeSchool of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
D J ButtleDepartment of Infection and Immunity, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
I R DuceSchool of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
M C GarnettSchool of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
University of Nottingham · GBUniversiti Sains Islam Malaysia · MYUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant derived cysteine proteinases (CPs) have long been known to possess anthelmintic properties but have attracted renewed attention recently because of the acute need to discover novel methods for controlling helminth infections as a result of increasing drug resistance. However, surprisingly little is known about the stability of these proteins under typical storage and

Indexed as

AnthelminticCysteine proteinaseEnzyme activityPapaya latex supernatant

Identifiers

PMID34693054
PMCPMC8515243
OpenAlexW3201842619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.