Evidence map›Paper›PMID 34692976›Full record

ReviewAlzheimer's & dementia (Amsterdam, Netherlands)2021

Neuropsychiatric symptoms in Brazilians with mild cognitive impairment and dementia.

Robert S Wilson, Ana W Capuano, Carolina Sampaio, Sue E Leurgans, Lisa L Barnes, Jose M Farfel, David A Bennett

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Robert S WilsonRush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Ana W CapuanoRush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Carolina SampaioInstituto de Assistencia Medica ao Servidor Publico do Estado (IAMSPE) Sao Paulo Brazil.
Sue E LeurgansRush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Lisa L BarnesRush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Jose M FarfelRush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
David A BennettRush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Rush University Medical Center · USHospital do Servidor Público Estadual · BR

Funding

African Ancestry and the Genomic Architecture of AD and Other Common Neurodegenerative Disease NeuropathologiesR01AG054058 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2016 to 2023
$8.9M
NIA NIH HHS R01 AG054058
6 · The paper itself

Abstract

introductionKnowledge is limited about behavioral and psychological symptoms of mild cognitive impairment (MCI) and dementia in racial and ethnic minorities.

methodsAs part of the Pathology, Alzheimer's and Related Dementias Study (PARDoS), we interviewed knowledgeable informants of 2319 older Brazilian decedents (67% white, 11% black, 22% mixed) using the informant portion of the Clinical Dementia Rating Scale to classify MCI and dementia and the Neuropsychiatric Inventory to assess behavioral and psychological symptoms.

resultsWe identified four clusters of neuropsychiatric symptoms: agitation, affect/apathy, psychosis, and behavioral problems. On the Clinical Dementia Rating Scale, 1407 had no cognitive impairment, 180 had MCI, and 732 had dementia. Both MCI and dementia were associated with symptoms in each behavioral/psychological cluster (all

conclusionMCI and dementia are associated with elevated behavioral and psychological symptoms in older black and white Brazilians.

Indexed as

dementiaLatinxmild cognitive impairmentneuropsychiatric inventoryracial differences

Identifiers

PMID34692976
PMCPMC8515552
OpenAlexW3205568168

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.