Evidence map›Paper›PMID 34692901›Full record

ArticleACS photonics2021

Micromirror Total Internal Reflection Microscopy for High-Performance Single Particle Tracking at Interfaces.

Xuanhui Meng, Adar Sonn-Segev, Anne Schumacher, Daniel Cole, Gavin Young, Stephen Thorpe, Robert W Style, Eric R Dufresne, Philipp Kukura

Open access · hybridAbstract read
In one paragraph

Article in ACS photonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Optical voltammetry of redox processes inside a nanohole with opto-iontronic microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Dark-Field Scattering Imaging and Spectroscopy.ACS applied materials & interfaces · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Cascaded momentum-space polarization filters enabled label-free black-field microscopy for single nanoparticles analysis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Xuanhui MengPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3TA, U.K.
Adar Sonn-SegevPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3TA, U.K.
Anne SchumacherPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3TA, U.K.
Daniel ColePhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3TA, U.K.
Gavin YoungPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3TA, U.K.
Stephen ThorpePhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3TA, U.K.ORCID https://orcid.org/0000-0002-1601-7582
Robert W StyleETH Zürich, 8092 Zürich, Switzerland.ORCID https://orcid.org/0000-0001-5305-7658
Eric R DufresneETH Zürich, 8092 Zürich, Switzerland.ORCID https://orcid.org/0000-0002-3091-5039
Philipp KukuraPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3TA, U.K.ORCID https://orcid.org/0000-0003-0136-7704
University of Oxford · GBETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single particle tracking has found broad applications in the life and physical sciences, enabling the observation and characterization of nano- and microscopic motion. Fluorescence-based approaches are ideally suited for high-background environments, such as tracking lipids or proteins in or on cells, due to superior background rejection. Scattering-based detection is preferable when localization precision and imaging speed are paramount due to the in principle infinite photon budget. Here, we show that micromirror-based total internal reflection dark field microscopy enables background suppression previously only reported for interferometric scattering microscopy, resulting in nanometer localization precision at 6 μs exposure time for 20 nm gold nanoparticles with a 25 × 25 μm

Identifiers

PMID34692901
PMCPMC8532162
OpenAlexW3206619971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.