Evidence map›Paper›PMID 34692846›Full record

ArticleBioMed research international2021

Specific Cytokine Profiles Predict the Severity of Influenza A Pneumonia: A Prospectively Multicenter Pilot Study.

Yu Xie, Yan Yu, Lili Zhao, Pu Ning, Qiongzhen Luo, Ying Zhang, Lu Yin, Yali Zheng, Zhancheng Gao

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026
    Review
  2. Article
  3. Article
  4. Clinical Characteristics and Cytokines of Children With Lower Respiratory Tract Infection Caused by Influenza A After COVID-19.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  5. Article
  6. Review
  7. Innate immune role of IL-6 in influenza a virus pathogenesis.Frontiers in cellular and infection microbiology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Comparing the Cytokine Storms of COVID-19 and Pandemic Influenza.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yu XieDepartment of Respiratory & Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, China.
Yan YuDepartment of Respiratory & Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, China.
Lili ZhaoDepartment of Respiratory & Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, China.
Pu NingDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 West Fifth Road, Xi'an, Shaanxi, China.
Qiongzhen LuoDepartment of Respiratory and Critical Care Medicine, Beijing Tsinghua Changgung Hospital, 168 Litang Road, Beijing, China.
Ying ZhangDepartment of Respiratory & Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, China.
Lu YinDepartment of Respiratory & Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, China.
Yali ZhengDepartment of Respiratory & Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, China.ORCID https://orcid.org/0000-0002-0359-2799
Zhancheng GaoDepartment of Respiratory & Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, China.ORCID https://orcid.org/0000-0001-7415-1416
Peking University · CNXiamen University · CNBeijing Tsinghua Chang Gung Hospital · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeStudying the cytokine profiles in influenza A pneumonia could be helpful to better understand the pathogenesis of the disease and predict its prognosis.

resultsA total of 35 patients with influenza A pneumonia were included in the study. The levels of IL-6, IFN-

conclusionSignificant dysregulation of cytokine profiles can be observed in patients with severe influenza A pneumonia.

Indexed as

AgedBiomarkersCytokinesFemaleHumansInfluenza A virusInfluenza, HumanInterleukinsMaleMiddle AgedPilot ProjectsPneumoniaPrognosisProspective StudiesROC CurveSeverity of Illness IndexBiomarkersCytokinesInterleukins

Identifiers

PMID34692846
PMCPMC8528594
OpenAlexW3207306551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.