Evidence map›Paper›PMID 34692693›Full record

ArticleFrontiers in cell and developmental biology2021

Gambogenic Acid Induces Endoplasmic Reticulum Stress in Colorectal Cancer via the Aurora A Pathway.

Cheng Liu, Jiaxin Xu, Chenxu Guo, Xugang Chen, Chunmei Qian, Xing Zhang, Pinghong Zhou, Yifu Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Cheng LiuExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jiaxin XuEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Chenxu GuoEastern Hepatobiliary Surgery Hospital, Shanghai, China.
Xugang ChenExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chunmei QianExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xing ZhangExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Pinghong ZhouEndoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Yifu YangExperiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai University of Traditional Chinese Medicine · CNEastern Hepatobiliary Surgery Hospital · CNFudan University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is one of the most common malignancies in the world and has a poor prognosis. In the present research, gambogenic acid (GNA), isolated from the traditional Chinese medicine gamboge, markedly induced apoptosis and inhibited the proliferation of CRC

Indexed as

Aurora Acolorectal cancerendoplasmic reticulum stresseukaryotic translation initiation factor 2αgambogenic acid

Identifiers

PMID34692693
PMCPMC8526855
OpenAlexW3204895381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.