Evidence map›Paper›PMID 34692675›Full record

ArticleFrontiers in cell and developmental biology2021

Intracellular Lipid Accumulation and Mitochondrial Dysfunction Accompanies Endoplasmic Reticulum Stress Caused by Loss of the Co-chaperone

Matthew J Jennings, Denisa Hathazi, Chi D L Nguyen, Benjamin Munro, Ute Münchberg, Robert Ahrends, Annette Schenck, Ilse Eidhof, Erik Freier, Matthis Synofzik and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Macrophage-Derived Extracellular Vesicles Deliver Progranulin to Alleviate Skin Wound Fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  8. Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  12. Highly specific σProceedings of the National Academy of Sciences of the United States of America · 2023
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  13. Article
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  15. Highly specific σbioRxiv : the preprint server for biology · 2023
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  16. Article
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  18. Neuronal p58Cells · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Matthew J JenningsDepartment of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Denisa HathaziDepartment of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Chi D L NguyenLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany.
Benjamin MunroDepartment of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Ute MünchbergLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany.
Robert AhrendsLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany.
Annette SchenckDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands.
Ilse EidhofDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands.
Erik FreierLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany.
Matthis SynofzikDepartment of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Rita HorvathDepartment of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Andreas RoosLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany.
Leibniz Institute for Analytical Sciences - ISAS · DEUniversity of Cambridge · GBRadboud University Medical Center · NLGerman Center for Neurodegenerative Diseases · DE

Funding

Medical Research Council G1000848Medical Research Council MR/N010035/1Medical Research Council MR/N025431/1Medical Research Council MR/N025431/2Medical Research Council MR/V009346/1Wellcome Trust
6 · The paper itself

Abstract

Recessive mutations in

Indexed as

cholesterol-stressDNAJC3mitochondriaproteomicsunfolded protein response (UPR)

Identifiers

PMID34692675
PMCPMC8526738
OpenAlexW3201843736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.